OK going to try to fix this, whatcha think?

Member Stories
#81

The concept of testosterone metabolism, and how to upregulate it via upregulation of overall metabolism (thyroid + cortisol), has been recently introduced in the homepage of Dr Crisler’s forum (link below). Since he is considered an authority in the field of hormone modulation, and since he allows this post to be a sticky in the homepage, I think that this is enough of a reference. If you want scientific sources to back up this concept, you should contact Dr Crisler or chilln (the administrator of the forum). I’m sure they can tell you the scientific reason of having such post on the homepage.

musclechatroom.com/forum/content.php?117-hormone-modulation-therapy-101

#82

Jacobs wants me to get my cortisol down…

All in all I believe my results further prove that low 5-AR-2 and low 3-Adiol-G is the culprit behind our situations… having exhausted essentially most avenues of treatment I am considering using cyclosporin A in an attempt to up-regulate these.

#83

One of the best finds i’ve seen since ive been on this forum.

I honestly think this supports my view that an AI can help counter some of finasterides effects in certain candidates (high estrogen, shrunken prostrate!!)

#84

last line is interesting, especially “increase in testicular volume.”

CONCLUSIONS: Dual inhibition of 5-alpha-reductase and aromatase resulted in a significant increase in prostate volume, accompanied by a 3-10-fold increase in serum testosterone levels and a significant increase in testicular volume.

so what are you planning? fin+arimidex or just arimidex?

#85

Are you crazy?

#86

I was thinking of dustasterine and arimidex.

I’ll keep going until my penis falls off!

…yeah. Arimidex. Small doses in the hope for a progressive effect.

#87

I second that! Overall, I dont think it is good for me. Alcohol makes things too inconsistent… But I have had some occasions where I felt totally normal! I wonder if it is SWELLING IN THE PROSTATE and NERVE PRESSURE or something like this. When I drink a ton my body gets totally relaxed. I have fucked like a pornstar.
Again, this is very inconsistent, and the majority of the time it is not effective, so I try not to drink much. It is only these experiences, however, that suggest these causes!

#88

alcohol inflames the adrenal glands.

#89

As of the last few weeks I almost always have morning erections to some extent. My regular erections seem to be about 80% of what they used to be. Penile shrinkage is only noticable when flacid (but I’ve always been a grower not a show’er).

The main problems sexually right now are severe lack of libido, limited sensation in the penis and reduced ejaculate volume.

I am still avoiding sex for the simple reason that even thou I can get hard quite easily (expecially with viagra)… I don’t think I will be able to maintain it due to the nonexistant libido and sensation.

I am also continuing to have sleep issues, depression and fatigue. Still need to get more tests done in regards to my high cortisol. I ordered a bunch of stuff recently (DIM Plus, Maca, Yohimbe, 3,6,17-Androstenetrione) So I’ll see how this works.

Edit:

As the amount of supplements I’ve taken increases and I continue to see little benefit my hopes of recovering dwindle. And I face the reality of being stuck like this for the rest of my life.

Which is unacceptable.

Thus I am giving it one last shot with another doctor a renowned sexual health specialist. But due to lack of understanding in the medical community regarding this issue I am not holding out much hope.

This drug has already cost me more than I can bare mentally, and its cost me in the bedroom and with some girls I actually felt could have been worth it long-term. Not to mention the fact that I haven’t felt remotely the same since taking finasteride.

I’m not certain what I am going to do if this doctors visit doesn’t pan out. My future looks rather bleak if I continue on like this (even though I have a great job, very prestigious with good pay) with the possibility of a relationship and family disappearing in front of me.

I’m 28 now, I feel I didn’t really get to enjoy life and being with someone because before the finasteride I never had a serious long-term relationship, and then afterward… well it just all fell apart.

We don’t know what causes this, but we have some very good ideas. I don’t know what my future holds but I hope that an answer will be found… for myself I just don’t know what tomorrow is going to bring.

#90

Had thyroid hormones run today… should have results in a few days.

Also got a script for yocon (yohimbe HCL) from my doc hopefully it helps.

#91

Thyroid Results Help me interprete this…

TSH, 3rd Gen: 0.61 (0.40-4.50)
T4 Free: 1.4 (0.8-1.8)
T3, Total: 71 (76-181)

So my TSH is borderline low, and my T3 is below the range. What does this mean? I’m hypothyroid?

PS:

So far my Test, Free Test, Estrodial, DHT, prolactin, LH, FSH, and SHBG are all relatively normal (my DHT does fluctuate considerably thou)

My 3-Adiol-G is below range low at 256 (260-1500)
My Cortisol is above range high at 72.2 (25-55)
And now I have these thyroid measurements.

#92

Another one with bad thyroid!

#93

You didn’t test RT3? That’s very bad.
How did you test your cortisol? Serum morning sample? If so, bad idea. Most people with cortisol issues have low cortisol later during the day, so serum morning is usually useless.

#94

What is best? 24hour saliva along with am and pm serum?

#95

I asked for rt3… thought he ordered it… my Cortisol was measured with 24 hr urinary. I also just did the dexmethasone serum test.

#96

New Testosterone results… under normal circumstances I should be running around with a hard-on 24/7 with these blood measurements…

Serum Test: 822 (250-1100)

Free Test: 246.1 (35-155)

Yes my FTest is out the window… I took a tab of letrozole about a week before the test.

Yet still I feel very little. Also interesting is that when I took a dexamethasone suppression test… the morning after I took the dexa I woke up with the best morning wood I’ve had since I was 15.

#97

The lack of 5 alpha reductase type 2 results in less progesterone being converted to the neurotransmitter allopregnanalone. Drinking alcohol helps release allopregnanalone (as does heroin).

#98

ncbi.nlm.nih.gov/pubmed/16168471

Finasteride-treated males were able to mate with untreated females which became pregnant but exhibited increased rate of pre-implantation loss. The subfertility observed was probably due to abnormally shaped sperm, since the sperm number was not altered. While plasma testosterone was enhanced, LH levels were not changed. The copulatory potential was not affected and all finasteride-treated rats presented male sexual behavior. Despite this, 53% of them showed homosexual behavior when pretreated with estradiol, suggesting an incomplete brain defeminization. These results indicate that 5alpha-R2 acts in brain sexual differentiation of male rats. Moreover, we suggest that 5alpha-R2 not only produces essential metabolites that act together with estradiol in brain sexual differentiation but also protects the brain from the damaging effects of estradiol excess.

How the hell could they possibly put this crap out into the public when it causes this in freakin animals? Unreal.

#99

So far treatments tried:

Lovastatin+ezetimibe (no results)
HcG+HMG+tamoxifen 1 month (very little results while on)
Clomid - intermidently (little results, some increase in morning erections while on)
DHEA (large doses, 200mg+ I noticed a substantial increase in morning erections)
Anactrim (no results)
Wellbutrin (no results, didn’t even help mood much)
naltrexone (no results)
tribulus (very slight effect, still run it ED)
DIM plus (haven’t noticed much so far been on it 1 week)
yohimbe (haven’t noticed much)
Maca (didn’t notice much, and it tastes terrible)
Dexamethasone - supression test - (had best morning wood in years the day after I I took this stuff.)
Burpronorphine (noticed my libido return for a day after trying this, didn’t last thou… and this isn’t something to play around with)

numerous herbs, vitamins and oils: (nothing)

I have some triptorelin on the way (GnRH, I will try this as it is suppose to kick FSH/LH into gear in small/single doses… not to be taken in large doses over a period of time as it will shut down natural production by the HTPA)

#100

Interesting.

I think it’s time for you to try the raw veg, lean protein, no sugar or carb diet. And take some pau d’arco tea.