Awor said that those who have PFS have a predisposition and thats why we are affected while others are not. But, I took the drug for several months and quit it and had no problem whatsoever. Then I took the drug for four days and now have been having side effects 8 months after quitting. Others took it for years and didn’t have a problem, then suddenly something triggered it in them. I don’t really buy this genetic predisposition. I think that eventually if you keep taking it, you will have issues. I don’t know how the research will explain the genetic predisposition but I’m waiting to find out, hopefully soon.
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Awor is not a doctor and he has no idea why we got stuck in this awful state of being. This is complete speculation on his behalf and unwarranted. You would think as a moderator he might be a little more prudent with his comments.
I don’t think Awor ment to say that anything he/we thus believe about PFS is absolute knowledge thus far, besides some of the few obvious things. And even if he did everyone who reads this site is an adult (for the most part) and should maintain a degree of skeptism regarding any “unproven” and/or “unconfirmed” information. Lest you find yourself on a plane to Greece to have doc stick his fingers up your anus. Nobody not even Awor said his (their) efforts are the eventual “holy grail” of finasteride research, he himself has been giving information out with a degree of caution, in part because I suspect he realizes that often times things do not turn out as expected. That said I look forward to any information that study reveals regarding our condition.
If someone feels there is a better research target then they can raise the idea here and perhaps with members of the scientific/medical community. But trying to redirect our entire sites focus away from an already ungoing research effort is not going to help any of us. More productive would be generating mass media attention as I have said several times, in the hopes that more and more scientists/doctors will become interested and focus on studying the subject using whatever approach they see fit.
In terms of finding new research aims I’m at a loss. Hormones can’t explain our symptoms as some people have normal hormones, others don’t, but have similar symptoms. I guess low 3a-diol G is a marker, but I have normal 3a-diol G and still have symptoms. I also have normal DHEA and those other obscure hormones. There may be neurohormones or signals that doctors don’t know about that are crucial for sexual function.
Then there’s the idea that our brain chemistry has been rewired as suggested by Irwig. The idea that some nerves have been damaged by Traish. There’s the fact that some have been diagnosed with neuropathy. Its all over the place.
I personally have ruled out auto-immune. I saw a really good rheumatologist and a really good immunologist and both agree its not auto-immune. I went to a neurologist who says the nerves seem fine (but btw totally believes me and was upset about the ease at which people can get prescription drugs), but recommended I see a neurourologist who may be more helpful. So now I found a really good neurourologist who is very involved in research at a very good university. I will be seeing her and her group actually in a month or so (I am scheduling my appointment and travel etc. as she’s not in my city). I actually wonder if she, or another doctor in her group, would be interested in possible research concerning this problem. She knew all about SSRI, Accutane, and Propecia persistent side effects.
Meanwhile, since early December I’ve been in the care of an endocrinologist who says I was the fourth person to come to him with this same problem from the same medication. He had me on clomid for a while and then tapered me off. I just recently tapered off. I’m going for a follow up with him in May. I feel as though he cares and wants to help me and is really interested/curious about this problem. For him I also wanted to mention thyroid treatment as my family has a history of thyroid problems (although no single male in my family has has ED issues, and actually the men in my family are hypersexual if anything, as I was before this).
So what is the theory here?
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If you are referring to genetic predisposition, my theory is that there is no genetic predisposition.
Another thing I personally have not eliminated is the liver. The liver has so many functions and makes so many important molecules. The liver detoxes and processes estrogen, testosterone, and progesterone. I wouldn’t be surprised if we have some sort of liver damage contributing to our systems (don’t think this is everything though). The more I read about the liver (have extra time to get ahead on my medical school studying now that my cock is fucked up), the more I think it may contribute to our problem. Which makes me think, maybe it wouldn’t be a bad idea to check in with a gastroenterologist.
Also, many of us have low Vitamin D. Vitamin D is processed in the liver and then kidneys in order to become active. Maybe its not properly making its way through the liver?
go for liver detox profile test. I don’t where to get it though. The_ruffneck was the only one to get it done.