Neurosteroid Biosynthesis Upregulation

[Belikewater]

Very interesting topic as I suffer from PTSD and anxiety myself. Thank you!

BeLikewater

[Belikewater]

@moonman1

Now that we have solid proof that finasteride and 5ar inhibitors can downregulate nuerosteroids even after discontinuation, perhaps we should look deeper into compounds that upregulate neurosteroid biosythesis. Hopefully a few of us will be able to get our hands on some of these to test out.

Ganaxolone
An allopregnenolone analogue. Just finished up human trials and proven to be safe.
marinuspharma.com/ganaxolone.html

Olanzapine and clozapine
Olanzapine and clozapine increase the GABAergic neuroactive steroid allopregnanolone in rodents.
mendeley.com/catalog/olanzap … e-rodents/

Selective Brain Steroidogenic Stimulants
A new class of drugs - whose mechanism of action involves the stimulation of neurosteroidogenesis with the goal of increasing brain allopregnenlone levels. Found to elecit potent neurosteroidogenesis activity selectively at a low dose.
…these include…

Flouxetine (Prozac) and Norfluoxetine (Seproxetine)
Fluoxetine and norfluoxetine stereospecifically and selectively increase brain neurosteroid content at doses that are inactive on 5-HT reuptake.
ncbi.nlm.nih.gov/pubmed/16432684
Important point here are that these can be taken in low enough doses that it will not affect the Serotonin pathway…

Neurosteroid Biosynthesis Upregulation: A Novel Promising Therapy for Anxiety Disorders and PTSD
intechopen.com/books/anxiety … s-and-ptsd

Regarding the solid proof. Can I see where did you read that?

[depressedguy]

ncbi.nlm.nih.gov/pubmed/24717976

[Sugarhouse]

anyone tried any of these treatments?