Neurological-based Treatment?

General Discussion
#1

It’s been nearly one full year since I had my brief Phenibut recovery, and am postulating this thought only because it’s something to consider…

How could a strictly neuroactive chemical induce a revival of the endocrine system?

In my particular case, my brain fog was eliminated, testicle size increased and no longer drooped low, shrinkage began to considerably reverse, myalgia disappeared, I gained muscle/lost fat, and sexual dysfunction began to reverse. And, if there are some still intent upon dismissing this as a legitimate, lest we forget that ithappens and a few others are now in a state of good health due to using GHB. I wouldn’t raise this question if I saw an impact in hormone-based symptoms.

Now, I’m not suggesting we will arrive at a conclusion in this thread, and as a matter of fact there already are one or two theories, such as

  • dopamine possibly upregulating the androgen receptor
  • neurochemical revival over the HPTA

I simply wanted to keep this as a reminder of this unexpected benefit of using these substances as we mobilize into research and testing.

Just something to keep in mind… any comments are welcome…

#2

I whole heartedly believe that my problem is in my brain. I can FEEL it. I’ve said it many times before. When my brain is on track, and I’m feeling good, all of my problems, physical problems, disappear. To me, the connection is clear. When I say physical problems I mean the way my penis hangs, how full it becomes in the flacid state, ease of getting a great erection, sensitivity, etc.

When my head is off, so is everything else. This makes perfect sense due to the fact that libido starts in the brain and then works it’s way out from there.

One question though 3PM. I know your recovery was brief, so I guess I’m just wondering how you “gained muscle/lost fat” in such a short amount of time?

#3

Not really sure excluding an increase in metabolism, and my body became more anabolic.

#4

If it is only neurological it is hard to explain the strange bloodwork we are seeing. I have low free t and other weird things going on like low vitamin d. I think that’s why the phenibut didn’t work that well for me. I have a feeling 3pm’s hormone levels are close to normal and that’s why he was able to have his brief recovery. For me it’s going to take a lot more unfortunately

#5

CDnuts,

I agree with you. 6 months ago I thought my problem was in the pituitary gland as everything I read indicated this may be the case.

I believe I am starting to believe that all over again. I just had my GH tested last week and it came back extremely low. This is a direct hormone of the pituitary gland.

Tomorrow I am going for a test on my Adreanals, Thyroid T3 & T4, Monday I go for an MRI of the Pituitary Gland. Is it a tumor in the Pituitary gland? I thought this could be the case months ago, I will soon find out. I will post the results for you guys as soons as I know.

I’ll let you guys know, Boston

#6

Joetz,

I think the low vit D is just side effect of low T; they go hand in hand.

The one thing that really makes sense is our Pituitary glands are screwed up. That is like the central command system for the hormones of the whole body. That would explain neurological problems and why when we are around women we find atractive we don’t respond the way we used to.

#7

My last work-up was 12/08, but the readings were abysmal, with T at the absolute bottom of the range, and low gonadotropins. I have every indication of endocrine dysfunction and hypogonadism, from smaller, lower-hanging testicles to muscle atrophy. Disagree completely with the idea that my hormones are normal.

Unlikely, since a pituitary tumor has never been found to be the culprit here.

I obviously concur that the HPTA is downregulated, which is essentially what you’re saying, but I disagree that it explains neurological issues. Perhaps some depression and listlessness from low T, but I think it’s possible we are facing something else, perhaps involving neurochemicals or receptors there-of. If a neuro-active chemical reverts an endocrine dysfunction, there is more to look into.

Something that I recall is that chems such as dopamine and GABA are paracrine/autocrine signaling hormones for the hypothalamus and pituitary; maybe it’s possible low levels collapse HPTA function.

#8

This goes hand in hand with what I’ve experienced. Say I increase the effectiveness of my Gaba channels by taking a small dose of xanax. Several interesting things happen. First, my flaccid hang get’s much bigger and looser, like it should be. Second, because the gaba is doing what it’s supposed to and there is not so much “static” in the lines, I can get aroused more easily. Because i can get aroused and feel arousal so much more then usual, my erections become bigger and harder than had I not increased the effectiveness of Gaba.

It’s not just when I artificially increase Gaba’s effectiveness either. When I’m having a better day then normal, and I’m feeling calm and centered, these same exact things happen. So, from what I’ve noticed, once my head is in the game, everything else just falls into place like it should.

For me, it all starts with Gaba doing what it’s supposed to and keeping other interfering signals under control so that things work the way they were designed to. It starts in my head and cascades from there.

#9

I spoke with Dr. Goldstein in San Diego (free consultation) and he knows my urologist very well in New York. They were just at a conference together on Tuesday I believe.

Anyway, I told him about my loss of libido and other things and he said to ask my uro to maybe give Wellbutrin a try to see if it helps libido. I will definitely do this. Still though with the small dose of Clomid daily, i am still a little lethargic but can whack off fairly easily, have sex etc but I still get the low hanging balls after I ejaculate and sometimes during the day…

Started wearing the zinger during the day at work, getting bloods tomorrow, just hope i am not insensitive to some of these meds…

Would wellbutrin help with gaba channels?

#10

Wellbutrin is a DNRA - dopamine/norepinepherine reuptake inhibitor, so it doesn’t have any significant action on GABA.

Here are more things to consider:

propeciahelp.com/forum/viewtopic.php?t=2313
“The neurotransmitter gamma-aminobutyric acid (GABA) plays an important role in the regulation of pituitary gland function…”
“GABA … directly regulates the secretion of the pituitary hormones PRL, GH, LH/FSH, TSH, and ACTH”

GABA-B Agonist Reverses Negative Feedback Effect
propeciahelp.com/forum/viewt … 0281#20281
“Infusion of baclofen … resulted within 1 h in the onset of frequent and robust GnRH pulses … followed either immediately or gradually by coincident LH pulses.”

Also note that Sustain Alpha contains “7,8 Benzoflavone” which is supposed to work on GABA in the HP axis in the same way.

I will say this, though - during my experminemt last year, it was when I began feeling an energy surge of dopaminergic concentration and mental sharpness that the recovery began, followed by more beneficial deep sleeps which included many erections and positive changes in my testicles.

#11

I would like to contribute my personal experience. During the worst time
when i had so many sides xanax 0.5 mg is a godsend. It helped with
my sleep, it even gave me a soft morning erection. Thanks god for my
doctor who prescribe it.

Does 5AR I and II has affinity to gaba receptor or is needed in gaba production in the brain ?

#12

Uhm, yes. Both enzymes metabolize 5AR-reduced neurosteroids (Allopregnanolone, THDOC) which normally would act on GABA-A receptors in the brain. However, by blocking 5AR with Fin or Dut, you inhibit this process.

propeciahelp.com/forum/viewtopic.php?t=202

Surprised you didn’t know this already considering the STICKIES at top of Mental Side Effects subforum.

#13

There is something with GABA agonists being effective.

Alcohol helps. 5a-DHP helps. Phenibut helps. Wormwood helps.

I’m not sure via what mechanism, however.