Did they tell you how androgen resistance could be tested before getting a treatment? Maybe some additional signs in the organism? Any ways to check the hypothesis?
I guess, the treatment must include some very potent drugs and could have some possible adverse effects.
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doctors suspected a hypogonadism in me, but my hormone tests were always within the normal range. some psychological tests were done and it was checked whether I had any trauma-induced sexual dysfunction. They eliminated this possibility as well, even the psychiatrist I went to said that he believed in me a lot, and he was absolutely sure that these changes in my brain and body were not in my head. some possibilities remain: loss of libido due to prostate atrophy, 5 alpha reductase deficiency androgen resistance, or an acquired androgen insensitivity syndrome.
Some stimulation tests were done. because dht measurement makes no sense without stimulation tests. dht release is also normal, so my 5 alpha reductase levels are normal. The only remaining possibility is that the cell is not responding to androgens or that the androgen receptor is not working. For this, they will initiate a virtual adolescence.
I will not tell the names of the drugs and the treatment protocol here, but dht and testosterone preparations are not used, some non-aromatized anabolic synthetic substances are used. And that’s very, very risky. I need to put certain signatures. The treatment will not be an aggressive treatment. I will be constantly followed. I hope it helps.
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actually some of the signs i saw in myself were very thinning of body hair. My hair is still bushy and there is not much shedding. loss of libido penile tissue was normal up to 6 months after stopping the drug but now appears to have thinned or the tissue has changed.
maybe this is actually a good thing because hair follicles in the body are very small. And that actually shows that the root cause is at the cellular level, if we can get the cells to respond again, everything will be fine. so we need to understand cells.
I was considering androgen insensitivity too. But there’re too many signs of androgens affecting my body like muscle development, return of acne and hair loss. My hormone tests were in the normal range too. And the endocrinologist said she could tell at the first sight that I didn’t have hyponogonadism.
Despite all of that I still have persisting symptoms, typical for PFS.
Could it be some partial insensitivity? I don’t have a clue.
I hope your doctors know what they’re doing. And I do hope you’ll find some helping treatment. Let’s keep our fingers crossed.
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How long ago did you experience hair loss?
The working principle of androgen receptors is not actually working or not working. Our bodies don’t work on a yes or no response most of the time. There is a spectrum that we can call healthy, normal and unhealthy abnormal.
When I searched the literature, I searched maybe hundreds of books. İt says that the androgen receptor will give certain signals to the cell incorrectly, in fact, it seems like it gives a pear signal instead of an apple signal, that is, apples and pears have similarities in shape and taste, but if we take the apple as normal, the pear will be wrong. This may actually explain your hair loss but your lack of libido and other symptoms (emotional breakdown, loss of reward sense, genital anhedonia).
I’m curious, could you explain these tests a bit more? Were they serum blood tests? My understanding is that DHT is made within the tissue it’s then used in, so measuring the tissue hormone level is difficult.
Man, this sounds like it could be quite dangerous… Remember that no Doctor fully understands what PFS is yet. Obviously it is your choice, but I don’t think it’s a good idea to rush into doing anything too crazy to try and treat this after less than a year of problems.
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DHT is measured after hcg injection. It is used in the diagnosis of male pseudohermaphrosis. hcg actually mimics lh.
DHT has a very short half-life, so direct blood measurements are wrong.
I really think you should wait longer before you do anything.
I’ve read 67 healing stories out of 1.7 thousand member stories, and I feel so hopeless. I don’t know what it means to feel better, I can’t understand the sentence I will feel better in a few years
A lot of people who heal move on with their lives and don’t come back. It happens. If you proceed with this there’s a very real chance you become much, much worse. Also, we are making progress with scientific research to uncover more about this condition.
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I’ve had the same thought. If there is some problem with the AR it sure we hell isn’t systemic. If it were we would be able to catch it on blood tests for sure.
But I don’t think it’s a coincidence that almost all the tissues that are affected in us happened to be tissues high in 5AR (muscle, penis, prostate, skin, brain etc).
Yeah it’s only 1 hour IIRC, and 99.9% of the serum level is bound to SHBG as DHT is not supposed to be a systemic hormone, but rather a paracrine one.
I really wonder how accurate a HCG stimulation test for DHT would be. It’s been shown that serum and intra-prostatic levels have zero correlation in several publications.
I really think one would need a tissue sample to draw any conclusions.
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I wish I had to sign a waiver before being given finasteride. Never would have fucking taken it.
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In a weird way it makes me feel slightly better about my situation that a simple plant based product sold over the counter could have done this to me. It’s weird Denmark banned saw but not fin. Go figure.
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Yes saw is sold by healthcare and nutrient companies. Finasterid is sold by the pharma war machine. No politician wants to loose his career attacking this most brutal cartel of the entire universe.
Well, I noticed sudden hairloss when I developed this syndrome after taking high dose of Accutane. According to my family history I must be predisposed to balding. Yet, there was not much of a change in a decade since I was 18. But then I suddenly noticed increasing hair shedding. I managed to stop it using Aminexill. A couple of months after I finished Aminexill treatment hairloss returned, seemingly less terrible. Maybe, it’s normal for my age, idk.
I’m afraid I don’t fully comprehend your apple/pear analogy. But you’re right about the symptoms. I don’t usually tell about the loss of reward sense among other symptoms(it seems very subjective to me). But I had come to conclusion there must be something wrong with it in me, even before I realized I had other symptoms.
I’m pretty sure there must be some signs of malfunction in our bodies. It’s not only that I feel different, there are some objective changes. The fact we aren’t able to catch it on blood tests doesn’t mean there’re no traces. Maybe it’s just a wrong spot to look at?
When I was taking Accutane I had my biochemistry checked at least once in a month. And there was nothing terrible, some parameters were elevated as expected. At the same time I suffered from various weird side effects, my body was obviously functioning far from normal. But according to my doctor(and the blood tests) my organism was tolerating the drug pretty good.
Alas I do.
The plant didn’t even do anything for my hair. It just destroyed me.
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I don’t feel my feelings in the past, when I was talking to someone, I could always feel the emotions in their words, but now I neither have my own feelings nor can I understand the feelings of the other person, even when someone approaches me well, I just feel angry and I try to suppress it.
The androgen receptor may also affect other receptors because many receptors affect the function of other receptors by superposition.
Man I think I’m giving up hardest day of my life
This condition is relentless and shows no mercy at all.