I was dealing with some depression issues at the time and low T seemed like an easy answer and I got stuck in a tunnel vision. Now I understand that it is much more complex than that. And that mistake has been costing me years of my life and feeling these symptoms everyday.
Upregulated ER seems plausible but the question is, how to fix it? I did one or two very small trials of low dose AI in hopes of them alleviating symptoms but nothing positive came out of it. It was years ago though. Both times were done with non-steroidal AIs though so when I stopped there most likely was a rebound in estrogen which only made things worse. I read from another member on this forum that anything he did that raised his estrogen levels made his AI syndrome symptoms worse.