I’ve split the thread so this one is on it’s own.
I have a brother, and he would likely participate if I asked him. I would need details before committing of course.
My brother took antidepressants some time ago.
I have a brother, but i’m from Spain.
Likewise, I live in England. Is it possible for people to get it done in Europe somewhere and then get the samples sent over? If not, I am very happy to help fund travel for others (especially with brothers!) though. If it has to be done in American and you can’t get enough people, I may be able to make it over there, work allowing. I have got a brother who is four years older than me - he may count as overweight, but if not I can ask him. Let me know if you don’t get enough people.
Awor: this is very encouraging, and gives great hope. Thank you.
Is this study one of the six that where anounced some time ago?
I do not have a brother but I wanted to make Awor and potential study designers aware of this company and product if the study intends to examine any genetic changes:
pacificbiosciences.com/appli … ification/
They have a sequencing product that can apparently detect most forms of base pair modification IE: methylation
BASE MODIFICATION DETECTION
Automatically detect DNA base modifications such as methylation on the PacBio® RS
DNA base modifications are important to the understanding of biological processes such as gene expression, host-pathogen interactions, DNA damage, and DNA repair. Traditionally, it has been difficult for scientists to study the more than 20 types of base modifications that occur in nature. Most studies to date have focused solely on cytosine methylation using indirect detection methods. Given the central role of base modifications in a wide variety of natural and disease processes, the ability to detect these changes is key to a more complete understanding of biological function.
Single molecule, real-time (SMRT®) Analysis software works by measuring the rate of DNA base incorporation during sequencing. This information, automatically gathered during the sequencing process, is a unique feature of our SMRT technology. The initial software release simplifies the process of detecting base modification events in native genomic DNA through a user-friendly analysis and visualization interface.
Come on everyone, we need people to respond to the poll. There must be more people than this who want to help get treatments or possibly a cure. This looks the most promising news yet for PFS sufferers, but only very few seem willing to do something about it. I wonder if one of the administrators could send this to everyone, because otherwise we will never get enough people at this rate.
would cousins work? i have male cousins from both sides of my family who might be willing to take part.
Do you only have 5 people in the case group right now? Why not in addition get in contact with people taking finasteride right now? There must be tons of those and the changes seen there are probably even more significant.
yes
Cousins are better than complete strangers as controls, because they still have a genetic, albeit more distant link.
That is an interesting control group too, but is not the focus of this study. It may be investigated later, though.
I have a cousin who also has PFS sides although not as bad as mine if that’s helpful at all in the future. His sides are pretty much the same as mine just not as severe.
boston332 … i am sorry to derail the thread, but i am curious, did your cousin attempt hormone replacement therapy? maybe he is not as severe because he did not attempt that and you did? i seems pretty clear from awors poll on this subject that people do NOT respond well, and i recall you mentioning that you had attempted this.
i have male cousins on both sides of my family, so i am going to at least try to get them to participate … better than nothing!
perhaps sending this poll out in an email blast will be more eye catching, because this is a very, veyr important poll
Thanks Lennon,
I could not agree more - this research could lead us to the answers we need, but only a handful of people seem interested in helping out. It is incredibly frustrating. Please could an adminstrator do an email blast?
Yeah, there may be people willing to participate who simply don’t log in that regularly. The poll has only been up for a bit over a week and it’s likely a lot of members are simply not aware.
I have a brother with Marfan Syndrome who has taken Atenolol for years and years (I’m not sure if that matters?). He is only two years older than me, so he could be a candidate, and I would imagine he would be willing to help out. Obviously I have a stronger genetic link between him than with a stranger, but he and I are very different as far as brothers go… my folks are very different people, and I very much resemble my mother, while my brother very much resembles my father. Physically he inherited very different genes than I, and mentally I inherited the very anxious and borderline depressed personality (of which my brother seemed to get little to none). I’m rather ignorant regarding genetics, and maybe ignorant in general, but would this be a factor?
*I will always wonder how my personality type (predisposition to anxiety and depression) set me up for mental side effects… hopefully that’s something that might get answered in my lifetime.
Donkeyboy, I think it will be answerd, I think it will.
I have a brother but he is currently taking Propecia (with no side effects). I don’t think there is any chance he would be willing to do this regardless. But I will contribute by donating to the foundation again.
perhaps in another thread, do you think you can give a bit more detail about your issues with propecia, and then your brothers situation (i.e. how long he has used it etc. etc.)
I wonder will this study be taken seriously ? I dont mean to attack anyone involved in it I appreciate what their trying to do.
But its likely that merck and the scum who promote finasteride will try and cliam it was “biased” because people off this site were used in the study.