Idea: Cycling TRT to un-silence receptors

General Discussion
#1

If receptors were silenced by being “overloaded” with DHT upon cessation of Propecia, would it not stand to reason that they might be un-silenced by being deprived of DHT again for an extended period of time and then only very slowly being reintroduced to it in such a manner as to be able to handle it rather than being overloaded?

What if we went on TRT for 3 months or something (so as to be sure to shut down our natural production), then stopped administering our TRT and just waited for our natural production to slowly kick in again. Would that not potentially re-sensitize our androgen receptors?

Just curious. Where am I wrong? Why wouldn’t that un-do what Propecia did to us?

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#2

I’ve contemplated that for a while as well. While simple in principle, it assumes that reversibility is possible. But theory and practice don’t often align. I believe there were a number of members who went on TRT, only to quit, without any improvements. It’s hard to ‘mine’ the countless stories on this forum for accounts, but that’s just from memory.

I suppose that surge in DHT upon cessation of Propecia would later lead to a reduction in DHT, and thus the receptors should revert to normal. If an epigenetic change has happened, I don’t see how inducing another extreme event would somehow click them back into their original state. I wish all these things could be tried… if only testing them out wouldn’t be fraught with risk!

#3

You can cycle Proviron. It’s DHT. And safer than TRT.

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#4

It wouldn’t have to be an extreme event. You could do both sides very gradually so as to be very gentle transitions. The important thing would be to have the body strive for more receptors for an adequate period of time. Maybe it would take many cycles rather than only one like the people who tried TRT have done.

#5

Why do you say it’s safer than TRT? I don’t see the difference really. Either way you need to shut down natural T production.

#6

I did this very thing under Mark Gordon…Cycling TRT at very low dosage and clomid combine with a host of supplements and it helped for a while and then you have to stop as your baseline improves t a point and then it starts causing a great deal of bad effects…It varies for everyone some just get worse right off the bat with it others improve some then get worse etc…

#7

I’ve just started TRT myself it’s early days at the moment but in time I will give you an honest reliable opinion of the outcome but that won’t be for a few more weeks yet.
I have seen many people say trt put things right or at least gave them back their sexuality.
I have also read alot of trt failures but I have noticed that the failure rates are much higher when it’s been homebrew trt as self prescribed with no medical supervision.
Im doing trt by the book under the supervision of a urologist I’ve had blood tests done and been diagnosed with secondary hypogonadism.
The best advice is to get checked out by a urologist have blood tests see where your levels are then go from their.

If you are purely looking to increase receptor sensitivity I have read alot into tribulus if you take 1500mg a day it can increase receptor sensitivity hugely to the point it can correct issues with ED and libido etc.

Will update on trt when I’ve given it a fare trial.

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#8

Priviron does is DHT based but im not sure if it’s a good idea as a long term solution.

#9

I’m on TRT as well. Actually have been for a couple years (Nebido). Recently I got busy in life and didn’t realize how long it has been since my last injection, and accidentally went basically off of TRT for 3 months (injections last 3 months and one time I went 6 months between injections).

I was surprised to discover that I felt no ill effects when I went off. No low energy, distinctly lower libido, etc. However, then when I got a new injection to go back on, I suddenly had erections all the time and noticeably higher libido. I would even say a normal libido. However, my penile sensitivity didn’t change so I still couldn’t have sex.

It does make me wonder if I just kept doing this over and over again I might not get further improvements that might even address the sensitivity issue. I guess Nebido is a kind of ideal TRT for this kind of “gentle” cycling because of its very long half-time.

#10

It makes sense to a point mate.
Could I ask are you on trt due to finasteride ?

#11

The thing is, Proviron does not shut down your natural T production or HPTA when it’s used short term, under 100mg… It’s way more safer than TRT.

Study:


There is also another study which says it lowers some hormones: https://www.popline.org/node/506648 (pretty shitty and not a credible study in my opinion)

And the third one: https://www.ncbi.nlm.nih.gov/m/pubmed/6431212/

A negative study for us, lowered some hormones but cured prostate and urinary symptoms: (Because DHT enlarges the prostate?)

Reduced plasma T levels, but no supression of pituitary. Free test. remained same, although it has to be rise up due to blockage of T to SHBG binding. “Proviron also has a great affinity for SHBG, so when administered, it will bind to the SHBG, leaving more testosterone free.” (sentence from livestrong.com)

https://www.researchgate.net/publication/18687469_The_effect_of_mesterolone_administration_to_normal_men_on_the_pituitary-testicular_function

#12

dht shrinks the prostate? I thought the whole point of 5 mg finasteride is to lower DHT to shrink enlarged prostates?

#13

Whoops! My bad, i just wrote it wrong. Yeah its the opposite. Im editing my post.

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#14

I’m on it in attempt to restore libido lost after Accutane.

#15

Let us tknow how that works for you

#16

I have been thinking about this as well. After taking HCG for about a month then stopping for 2 weeks, at the end of the 2 weeks I felt pretty crappy/tired, but libido wise I was actually doing pretty decent (my main issue is lack of sensitivity and the resulting difficulty orgasming/long refractory period). Towards the end of those 2 weeks I wasn’t a walking hard on anymore but I didn’t have any trouble finishing once things got going, if you know what I mean.

I’m back on HCG now… planning on another month on and going to try a few weeks off again and see what happens.

I don’t know the science behind it, but I’ve seen a few stories of people doing similar with Clomid and it worked for them, so I guess I’ll be the guinea pig for this idea

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#17

Sounds good ncsugrad. I’m going to try etifoxine so will stay on the TRT for now (don’t have choice anyway since still have couple months left on this injection). But if etifoxine doesn’t work out then this is another thing that I will eventually try too. Looking forward to seeing what your outcome is.

#18

Was it work on your orgasm quality and sensivity too? Are you sustain those benefits after discontinuing?

#19

I don’t have good answers to these yet as I haven’t been consistent about it long enough to know. I’ve never had issues with orgasm quality, just sensitivity that gets worse and worse the longer sex lasts, so it can take a lot to get there (if at all–at some point it gets nearly impossible). I’d about rather have premature ejaculation issues at this point, lol

I remember towards the end of the 2 weeks of not taking HCG I didn’t have any trouble “finishing”, but wasn’t hard non stop, so it was kind of weird how those two things swapped. Sensitivity seemed better but erections seemed worse. While on HCG I was a walking hard on but still had issues finishing some of the time.

I just started back HCG a few days ago so we’ll see how things go. Haven’t noticed anything yet.

#20

TRT can take around 6 months for libido effects to , so 2 months might not seem beneficial, though they might be