l-glutamine increases HGH. glutamine is also one of the major pre cursors to gaba.
Thanks dude i know that. More discussion on hgh and low igf protein levels
Anyone know why my IGF-1 Levels are high and my IGF binding protein 3 are boarder line low?
It’s like there is some form of HGH resistance. High range IGF-1 and low IGFP3 with low levels of testosterone, some form of upregulation to make up for low T?..
Discrepant IGFBP-3 and IGF-1 results can sometimes occur due to liver and kidney disease; however, this is uncommon and such results should alert laboratories and physicians to the possible occurrence of a preanalytical or analytical error.
Though i know for certain i don’t have liver disease, though my liver has been enlarged since stopping propecia.
Hmmm…
I know it’s action is used to measure BPH. Though it’s effects on collagen production etc I don’t understand why the levels would be almost below range.
Any explanation would be great.
I have the same issue.
“IGFBP3 protein levels decrease during the progression of prostate cancer from benign prostatic hyperplasia (BPH) to its metastatic form.[3] Although, production of the protein does not cease completely. IGFBP3 is still made (at a lower level) by prostate cancer cells and secreted into the surrounding environment. However, instead of the full length, functional protein, IGFBP3 is found to be cleaved.[4] This prevents IGFBP3 from binding and sequestering IGFs and the growth factors are free to bind the IGF-1R and promote cell survival.”
Can you take anything out of that Pecker? really doesn’t make much sense to me when it’s main action is collagen production
It doesn’t appear to mean much for us. Just saying that for those suffering from prostate cancer it may enhance the survival of the cancer cells. Just something else great about PFS.
Pecker here’s a few articles
http://www.gdx.net/core/sample-reports/IGF1-IGFBP3-Sample-Report.pdf
“IGFBP-3 also regulates the interaction of IGF-1 with its receptor, and inhibits growth and induces cellular apoptosis
through IGF-independent mechanisms. Like IGF-1, most circulating IGFBP-3 is produced in the liver, where its
expression is positively regulated by growth hormone and downregulated by insulin. IGFBP-3 levels decrease with age
in normal adults, although to a lesser extent than IGF-1. IGF-1 has mitotic properties. Lower levels of IGFBPs,
especially relative to IGF-1, have been associated with increased risk and poor prognosis in several types of cancer.
Levels also tend to be lower with trauma, surgery, burns, and acute or chronic illnesses such as uncontrolled diabetes
mellitus and coronary arteriosclerosis.
IGFBP-3 binds the vast majority of IGF-1 in the serum, thus limiting its bioavailability. As IGF binding proteins are
positively regulated by hGH (and IGF-1), the IGF-1/IGFBP-3 ratio generally parallels increases or decreases in IGF-1.
Because of IGF-1’s mitotic properties, a higher IGF-1/IGFBP-3 ratio is associated with increased risk of developing
cancer, whereas a lower ratio correlates with a reduced risk due to less tissue availability of IGF-1. The IGF-1/IGFBP-3
ratio generally declines with age and/or growth hormone deficiency, and may be reduced by measures such as exercise
training, oral estrogens (although this effect is offset by progestogens), and/or insulin-sensitizing agents. Conversely,
higher ratios might be expected with hyperinsulinemia or conditions featuring excessive hGH, such as acromegaly.”
“status. Mean levels of IGF1 tend to be higher, and
levels of IGFBP-3 tend to be lower in premenopausal women
than in postmenopausal women”
biomedcentral.com/content/pdf/bcr1655.pdf
Further more i had extrememly low Aldosterone. Deoxycorticosterone —> Aldosterone
Do you think Kidney function may of been affected also, which can also jeoperodize IGFPB3 ratio.
“IGF proteins are important anabolic growth factors that are influenced by nutritional status, growth hormone, and general metabolic and disease status. In the present large cross-sectional study of U.S. adults, IGF-I and IGFBP-3 protein concentrations were statistically related to age, sex, obesity, diabetes, hypertension, dietary intake, and kidney function. Age-adjusted IGF-1, IGFBP-3, and the molar ratio of IGF-1/IGFBP-3 all increased with declining kidney function. Protein intake was lower in participants with impaired kidney function and was weakly correlated with IGF-I concentrations, however, strong differences between vegetable versus animal protein intake were not apparent. Thus serum IGF proteins, particularly IGF-I, were useful in predicting kidney failure in a population with widely varying kidney function. Additional studies are needed, however, serum IGF-I concentrations may be a useful marker of overall kidney function as well as a marker of nutritional status in kidney failure”
cancerres.aacrjournals.org/conte … 4.abstract
sorry for the big post.
I would say we have a chronic disease yes.
Good info but tells us relatively nothing about our condition… which appears to be effecting us in a multitude of ways…
I just don’t think igf or its binding protein is telling us anything special here besides we have a chronic disease so yes it’s gonna be messed up.
It all starts somewhere. You know if you’d ask me what a disease is i’d say it’s an abnormality in our system, really want to start opening new doors and finding out where it is.