Propeciashiz, read the story of -JN- He’s a long time sufferer and he credited HGH to getting him back to close to normal.
Growth Hormone stimulates IGF-1.
My IGF-1 was 2x above range 1 year post crash.
It is misleading to talk about your own personal test results because you didnt use Finasteride.
You just have some bizarre back story about taking saw palemtto at the age of 15.
You also reply to people when they ask what supplements work quite a bit - again this is misleading.
propeciashiz - I’d be interested in seeing an anti-aging doctor myself, although from doing a google search the U.K. doesn’t appear to be at the forefront of this particular field of medicine. Any guys in U.K. know of any decent anti-aging docs?
Hey Scotsman, Anti-aging doctors are generally biochemists or in the fields of sports medicine. So they may call them something else in the U.K. The benefit of a anti-aging doctor over a endocrinology is that they do extentensive testing which your general endo will not do. I will keep you posted as i’m heading to one tomorrow.
Cheers,
My IGF-1 is at the higher end of the range 3 off being over. Though IGF 1 Binding protein 3 is almost below range, which suggests it’s not being delivered to tissues correctly, if i’m correct IGF-1 P3 stimulates collagen production. HGH measured in serum bloods was below 0.5<, so not sure about this. Going to try further testing
For those suffering from premature wrinkles , sunken eyes.
en.wikipedia.org/wiki/IGFBP3
en.wikipedia.org/wiki/Collagen,_type_I,_alpha_1
[Size=4]“IGFBP3 protein levels decrease during the progression of prostate cancer from benign prostatic hyperplasia (BPH) to its metastatic form.[3] Although, production of the protein does not cease completely. IGFBP3 is still made (at a lower level) by prostate cancer cells and secreted into the surrounding environment. However, instead of the full length, functional protein, IGFBP3 is found to be cleaved.[4] This prevents IGFBP3 from binding and sequestering IGFs and the growth factors are free to bind the IGF-1R and promote cell survival.”
“Insulin-like growth factor-binding protein-3 expression and secretion by cultures of human prostate epithelial cells and stromal fibroblasts”. "[/size]
Taken from wikipedia.
Hey there propeciashiz. Hope that you got on okay at your anti-aging doc. I’d be really interested to know how you got on. How did you go about finding an anti-aging doc where you are in Australia? I’ve had a cursory search with the fields you suggested of biochemists and also sports science, although I’m really not sure where I am if such a specialist service is available in either field. Doing a basic anti-aging doc search predominately comes back with cosmetic options rather than any real science and understanding of the biological and hormonal which impacts on the aesthetic. The next step myself I feel would be to get a better understanding of what maybe happening hormonally. The general response from the medical profession seems to be pretty apathetic if it’s anything other than a cut and dried case of below range testosterone levels (for example), even if your levels are at the bottom end of the range and more like that of an old man.
I’d be very intrested to know if somone has had all IGF and IGF Binding proteins checked.
I checked the growth hormone level a couple of years back or so. I can’t remember the exact value, but I think it was 3. something. It’s supposed to be below 11,5 mIE/l in adults, so it was low if this was the case. I do have experience with hGH, and it (or IGF-1) is definitely a factor. In my experience, hGH enhances androgens effects on the body. After developing PFS, I haven’t had much problem with seborrheic dermatitis - which is an androgen-mediated disorder. hGH aggravates the condition. I’ve grown a lot of body hair while using it, and I can feel the beard grow sometimes after injecting. It aggravates androgenetic alopecia as well… I used 2 i.u.'s a day for 4 months. I was on TRT during this time.
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Thanks for your reply.
What i’m trying to understand is that my HGH is below 0.5 < and my IGF which is 90% of the range, though IGBP3 which is incharge of collagen production is greatly below range. I had very youthful skin before propecia and I am 21 should not be getting wrinkles. Aesthetically displeasing, though i know this is not a great deal. It may unlock so further questions with research I guess.
Hard to tell. Androgenetic alopecia has been linked to low levels of IGFB3, and other diseases like insulin resistance too. Insulin resistance is linked to growth hormone or its metabolite IGF-1. I’m just throwing out my thoughts here. The point is that you may have had low IGFB3 before using Propecia.
hGH is low because IGF-1 is high. It exerts negative feedback… The liver converts hGH to IGF-1, and is responsible for IGFB3 production, if I’m not mistaken.
l-glutamine increases HGH. glutamine is also one of the major pre cursors to gaba.
Thanks dude i know that. More discussion on hgh and low igf protein levels
Anyone know why my IGF-1 Levels are high and my IGF binding protein 3 are boarder line low?
It’s like there is some form of HGH resistance. High range IGF-1 and low IGFP3 with low levels of testosterone, some form of upregulation to make up for low T?..
Discrepant IGFBP-3 and IGF-1 results can sometimes occur due to liver and kidney disease; however, this is uncommon and such results should alert laboratories and physicians to the possible occurrence of a preanalytical or analytical error.
Though i know for certain i don’t have liver disease, though my liver has been enlarged since stopping propecia.
Hmmm…
I know it’s action is used to measure BPH. Though it’s effects on collagen production etc I don’t understand why the levels would be almost below range.
Any explanation would be great.
I have the same issue.
“IGFBP3 protein levels decrease during the progression of prostate cancer from benign prostatic hyperplasia (BPH) to its metastatic form.[3] Although, production of the protein does not cease completely. IGFBP3 is still made (at a lower level) by prostate cancer cells and secreted into the surrounding environment. However, instead of the full length, functional protein, IGFBP3 is found to be cleaved.[4] This prevents IGFBP3 from binding and sequestering IGFs and the growth factors are free to bind the IGF-1R and promote cell survival.”
Can you take anything out of that Pecker? really doesn’t make much sense to me when it’s main action is collagen production
It doesn’t appear to mean much for us. Just saying that for those suffering from prostate cancer it may enhance the survival of the cancer cells. Just something else great about PFS.
Pecker here’s a few articles
http://www.gdx.net/core/sample-reports/IGF1-IGFBP3-Sample-Report.pdf
“IGFBP-3 also regulates the interaction of IGF-1 with its receptor, and inhibits growth and induces cellular apoptosis
through IGF-independent mechanisms. Like IGF-1, most circulating IGFBP-3 is produced in the liver, where its
expression is positively regulated by growth hormone and downregulated by insulin. IGFBP-3 levels decrease with age
in normal adults, although to a lesser extent than IGF-1. IGF-1 has mitotic properties. Lower levels of IGFBPs,
especially relative to IGF-1, have been associated with increased risk and poor prognosis in several types of cancer.
Levels also tend to be lower with trauma, surgery, burns, and acute or chronic illnesses such as uncontrolled diabetes
mellitus and coronary arteriosclerosis.
IGFBP-3 binds the vast majority of IGF-1 in the serum, thus limiting its bioavailability. As IGF binding proteins are
positively regulated by hGH (and IGF-1), the IGF-1/IGFBP-3 ratio generally parallels increases or decreases in IGF-1.
Because of IGF-1’s mitotic properties, a higher IGF-1/IGFBP-3 ratio is associated with increased risk of developing
cancer, whereas a lower ratio correlates with a reduced risk due to less tissue availability of IGF-1. The IGF-1/IGFBP-3
ratio generally declines with age and/or growth hormone deficiency, and may be reduced by measures such as exercise
training, oral estrogens (although this effect is offset by progestogens), and/or insulin-sensitizing agents. Conversely,
higher ratios might be expected with hyperinsulinemia or conditions featuring excessive hGH, such as acromegaly.”
“status. Mean levels of IGF1 tend to be higher, and
levels of IGFBP-3 tend to be lower in premenopausal women
than in postmenopausal women”
biomedcentral.com/content/pdf/bcr1655.pdf
Further more i had extrememly low Aldosterone. Deoxycorticosterone —> Aldosterone
Do you think Kidney function may of been affected also, which can also jeoperodize IGFPB3 ratio.
“IGF proteins are important anabolic growth factors that are influenced by nutritional status, growth hormone, and general metabolic and disease status. In the present large cross-sectional study of U.S. adults, IGF-I and IGFBP-3 protein concentrations were statistically related to age, sex, obesity, diabetes, hypertension, dietary intake, and kidney function. Age-adjusted IGF-1, IGFBP-3, and the molar ratio of IGF-1/IGFBP-3 all increased with declining kidney function. Protein intake was lower in participants with impaired kidney function and was weakly correlated with IGF-I concentrations, however, strong differences between vegetable versus animal protein intake were not apparent. Thus serum IGF proteins, particularly IGF-I, were useful in predicting kidney failure in a population with widely varying kidney function. Additional studies are needed, however, serum IGF-I concentrations may be a useful marker of overall kidney function as well as a marker of nutritional status in kidney failure”
cancerres.aacrjournals.org/conte … 4.abstract
sorry for the big post.
I would say we have a chronic disease yes.
Good info but tells us relatively nothing about our condition… which appears to be effecting us in a multitude of ways…
I just don’t think igf or its binding protein is telling us anything special here besides we have a chronic disease so yes it’s gonna be messed up.
It all starts somewhere. You know if you’d ask me what a disease is i’d say it’s an abnormality in our system, really want to start opening new doors and finding out where it is.