What is common with all these symptoms?
is it sexual dysfunction?
no.
its not responding to drugs,alcohol,benzos,opiates etc…
When biologists or some smart guy knowing the subject would answer the non-response to drugs,than we are towards answering the pfs/pssd/pas solution…
Some people here can get drunk, some can’t. So it’s not that either.
my post asked if u can answer why is that happening,plz stick to the thread topic if u will
tnx
You said that it’s not sexual dysfunction. I agree.
You say it is not responding to, amongst other things, alcohol.
I’m just saying that response isn’t uniform there.
Where does it ask anything?
i disagree with the original poster
I completely disagree with the original poster
After extensive research and talking directly to some of this forums members I can say without a doubt that I seen more far more cases of sexual dysfunctions impotence penis shrinkage testicular pain loss of libido memory issues anxiety sleep disorders and depression than anything else.
Keeping in mind that I’m researching post finasteride issues and targeting finasteride side effects as this is the drug that I took .
My research has come from
Body building forums
This forum and people on this forum
Hairloss forums
BPH forums (proscar users)
Pssd forums
The story is always the same
No previous health issues
No previous sexual issues
No previous mental issues
The outcome for the minority that have side effects is always a combination of all the above listed issues.
u dont get the point,all of u
whatever…
Perhaps you could explain it again?
if u answer why some of us don’t respond to drugs,u can answer the root cause of pfs
Which drugs? Surely everyone would have to have the same response for that to be accurate?
Okay I get what you’re saying now, but thats not accurate. Who’s to say people here don’t respond to drugs? And what drugs are you talking about, every drug has a completely different chemical composition. Are you classifying illegal drugs like heroin and cocaine in the same category as pharmaceutical drugs like Truvada? Benzodiazepines? SSRI? PDE inhibitors? If you claim people with PFS don’t respond to drugs, whats the point in you undergoing Prep treatment? Thats an extremely general statement for several reasons.
Since some people respond to drugs/alcohol/etc., clearly the altered response of many others does not tell us immediately what the root cause is. But I think we already have a pretty good but basic idea what the root cause is and how this corresponds to the change in reaction to alcohol and other drugs of many PFS patients.
The altered reaction or non-reaction to drugs/alcohol/etc. of many people here is probably related to altered neurosteroids. We know that our neurosteroid levels are significantly altered compared to a control group, e.g. allopregnanolone was pretty much undetectable in the PFS patient group. There is evidence that the intoxicating reaction to alcohol is related to an increase in neurosteroids, among others the aforementioned allopregnanolone. If you do not respond to alcohol, it’s probably because your allopregnanolone levels are too low. Ironically, Finasteride has been considered to treat alcoholism.
The root cause, however, is a couple of steps further down the chain. The question is, of course, why neurosteroid levels are altered. The neurosteroids in question are metabolised by 3a-HSD which is driven by AR gene expression. In the end, all PFS/PSSD/PAS symptoms can be linked to reduced AR gene expression. And AR gene expression is probably reduced as a result of a negative feedback loop driven by overexpressed AR.