High Estradiol To Produce More Nitric Oxide

General Discussion
#1

This is simply a theory/possibility and something I want to look into more. After seeing the wide variety of effects of different foods on my system, I am trying to find a link as to why it’s happening.

I noticed 2 things that I have clear problems with: Vitamin E and Rosemary Herb.

Vitamin E and Rosemary Herb both give me a similar bad side effect.

Vitamin E and Rosemary herb have two things in common. They both decrease Nitric Oxide in the body and they both decrease Estrogen. I’m not sure if these are separate processes or the same process.
carcin.oxfordjournals.org/content/23/6/983.full (NO)
ajas.info/Editor/manuscript/upload/24-175.pdf (VE)

Now, I’m finding research that suggests that Estradiol helps to INCREASE nitric oxide production.
pnas.org/content/96/6/2788.short
sciencedirect.com/science/article/pii/001457939500124R

I know that nitric oxide has important factors in making either your penis become erect or allowing the blood to pool out of your penis. A lot of people report the “hard flaccid”/rubbery penis. This could very likely be due to lack of nitric oxide.

Now, our bodies simply aren’t just making estrogen for no reason here. The body adapts to what it’s up against.

What I’m wondering if it’s possible that our bodies are creating extra estradiol in order to create more nitric oxide because we are lacking in nitric oxide. Since estradiol has been shown to increase nitric oxide in the studies, it makes sense that if estradiol goes up than nitric oxide would go up.

It is also seen as a problem when we have high estrogen. So why would when I take something that is supposed to combat high estrogen give me negative effects? Clearly, my body must need the high estrogen for some purpose. Possibly for more nitric oxide?

Okay, so why is nitric oxide not being properly synthesized? This could be where the digestion issues come into play. NO is synthesized from l-arginine, an amino acid. Now this is the part I haven’t looked into too much. Perhaps finasteride somehow screwed up our ability to synthesize l-arinine properly, not allowing us to create NO. This would also make sense that all my food sensitivities mostly affect my penis, although other systems are affected as well like social anxiety, mood swings, dreams/lack of, among others commonly posted here. I’m not sure if NO has any effect on those systems, but something I will look into further.

Any feedback on this would be appreciated with your knowledge on these subjects. :slight_smile:

#2

Anything and its contrary may give good or bad results with this mess. The more I learn, the more I see there is absolutely NO rule, and something that makes you worse can make another one feel better, while you may get better with a pill that made the other one worse. This is crazy.

This is particularly insane considering the fact that everyone of us had the same root cause: external inhibiting of 5AR, then stop of external inhibiting. I’m really eager to see the day when we learn at last precisely which occurs in the body when we stop Finasteride.

#3

I hope we will see the day :slight_smile: .

#4

So do I. I can’t believe we still don’t know since it was SO FUCKING CATASTROPHIC!!!

#5

Try some other routes to reduce and promote estrogen without doing the same to NO for an extended period and see if you get the same result. Should be easy to test, right?

Search the site, Mew has posted studies on NO synthesis and you can follow a damage chain from finasteride. NO does indeed have wide ranging effects on the body however it’s not the solution and there is risk of developing tolerance to supplemented l arginine quickly.