Has anyone tried estrogen therapy or heard of the estrogen hypothesis?

Therapeutic Efforts
#10

I’ve taken E on/off since 2021 and consistently for a few years now.

It helps with every symptom to some extent and some it has gotten rid of. I had extremely severe PFS and so in the past it has been insomnia, shrinkage, brainfog, prostate pain, frequent urination, loss of libido and digestive issues amongst other things.

When E is working my brain works extremely well, I feel a deep connection to life and everything is better including how I look.

Unfortunately I’m very susceptible to changing response to hormones, so it’s hard to maintain all the good effects consistently, although I am for the most part consistently 70-80% better than before E.

I don’t respond as one would expect to E. I get both some female typical effects and also some male typical effects…

It certainly feels like a mutation; the actual response of tissues is all off and different.

If I stop E or increase T then I’m back to PFS nightmare as expected. The response to T is very unusual to say the least

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#11

Regarding the hypothesis that guy makes. His opinion keeps changing and so it seems more experimental and a working draft than anything else. I’m not part of it but I hear it’s basically ran like a dictatorship and he takes advantage of vulnerable people for his own benefit.

The theory now includes mifepristone. Some limited improvement is also expected based on mutation theory for PFS. It has even been used in research for CRPC with limited success.

If you’d like to read about a risky approach and also a more realistic rational why this could work take a look at Bipolar Androgen Therapy and understand why that can work. I of course want to believe but wanting to emotionally and seeing the evidence are two different things. BAT would be slightly different anyhow, it usually would involve extremes in testosterone levels to shock the mutation and to destroy it.

As treatment estrogen alone can do multiple things including reducing testosterone levels to castrate, it can bind to ER which is likely underexpressed in tissues with AR overexpression and also it can bind to mutations. All of this can create an environment that meets the new equilibrium needs and ultimately treat some PFS symptoms in theory. There are many questions that come from this, such as do we want to relieve symptoms at the risk increasing the growth / spread of the mutation.

I don’t recommend taking risks.

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#12

I’ve often noticed that some of the symptoms we have , are similar to women going through the menopause (dry skin, heat changes , severe insomnia , palpitations , anhedonia etc)
Of course this happens because their estrogen crashes …. I’m sure estrogen has something to do with it ……

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#13

It is not a male disease. Female pattern hairloss is caused by the exact same thing as male pattern hairloss. Anyone who knows my story- I have entirely disintegrating skin and cannot stand by a sunny window ever again/ knows women can get PFS. please do not spread misinformation. I’m going to die of skin cancer because of these medications. I have not found anyone whose connective tissue was destroyed by minoxidil and dut/fin to that level, if anything these drugs are even more dangerous to women.

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#14

I’m very sorry to hear that. Out of curiosity, is this a story you’ve shared on this forum?

#15

That’s very interesting, thanks for sharing.

#16

Thanks for sharing the information. Curious - and dangerous - stuff going on out there.

#17

Your experience is insanely valueable to me.
I have taken a few weeks of high dose Exemestane back in 2015 in an attempt to boost my T, which it did.
However, almost ten years later I still suffer from low E symptoms which are very similar to PFS symptoms.

What E protocole has made you feel better ?

#18

@Tyr ?

#19

What symptoms do you have?

#20

Extreme fatigue
Irritability
No libido or lust, just the ability to get hard when I see or smell a vagina
Flat muscles
No will to do anything
No pleasure listening to music

#21

Can you go to the gym? Do you have strength?

I had a severe crash with clomid

#22

Can’t go to the gym, can’t get a pump.
My muscles burn like crazy after 3 reps.

#23

Currently 2x Estradot 100mcg patches applied twice weekly.

In the past I used estrodiol valerate vials and injected 10-20mg per week.

Both these taken as monotherapy i.e. with no other hormone.

The suppression of androgens from high doses actually helps a lot with the symptoms.

#24

Thank you for your reply.

I just received my 2% estradiol cream.

Applying one full pump would provide 20mg estradiol, of which probably 2mg would be absorbed.

Would you advise applying that dose daily and see if symptoms improve or shocking the body with a higher dose less frequently ?

I was also planning on applying testosterone simultanously but will try estradiol on its own first.

#25

I think symptoms would likely improve with either way and “shocking” type treatment would likely bring acute effects.

Can’t really recommend tbh, but see it not as a cure and so you want to use what is realistic long term for you.

After a few years on E going back and trying testosterone was pure agony for me. The symptoms were probably just as bad as they were, at least. It’s scary and the downturn happened so fast.

I’m mostly recovered back to my E dominant baseline, but not fully. It has left me feeling a bit down with how dependent I am on hormones to just function as normal and not be in severe pain.

My goal for life right now is survive and to work on building my career, so that if I’m ever cured then I’ll be in an ok situation.

#26

So you have been using only estrogens without any androgen for a few years ?

Any type of feminization happened ?

#27

Yes I’ve been just on estrogen without androgens for years now.

Not much feminisation at all. My skin looks younger for the most part with some periods where I can look slightly more feminine. The appearance of my face / body can change at times.

If my body was normal I’m sure I’d feminise, so I see the lack of feminisation as just another PFS thing.

During the periods when I do look slightly feminine, I actually feel amazing… I assume estrodiol is able to work to a greater extent during these periods and produce even more neurosteroids.

Libido has changed from pre-PFS being very much straight and dominant, to PFS being asexual with short periods of less dominant libido and then with estrodiol to a significantly more feminine libido and not so straight. It’s very nice to feel something.

There have been many other good cognitive changes but unfortunately I don’t think others would fully understand unless they experienced it or were female. Estrodiol can open up certain feelings that aren’t usually felt by males and it can even seemingly dictate language / gait / way we connect to females / how we smell / behaviour / how we define pleasure etc etc.

If i’m ever cured, I’ll look back on my time with estrodiol and take a lot from the experiences. It potentially would be very hard to let go from some of it.

A good way to describe it and someone else with PFS also described it this way was estrodiol feels like one big hug. It at times is very relaxing and comfortable.

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#28

I have been trying an estradiol cream for the past 3 days.
Although I have found some sensations from the past, libido is not one of them.
It makes me feel too mellow for my liking.

I might make the trial last a few days longer and and see if I go back to a more healthy testosterone + progesterone protocole.

#29

Yeah sure sounds like a good idea.

I definitely wouldn’t recommend it if the deciding factors are such things as that. The factors should really be extreme like they are for me.

I miss the go-man extreme energy I used to have before PFS, but what E2 is doing for me is completely treat some issues like disabling brain fog. It enables me to do more than just about put food on the table and that’s the deciding factor for me.

For my case it definitely feels way healthier with the E dominance. My joints aren’t in pain, my cognition is clearer, I look way more rested, no more extreme insomnia, no more slurring words etc etc.

Libido wasn’t really even a consideration when I started because all I wanted was to at least be able to sleep and feel something. I was more than happy with what I got as a result.

…the libido changes as I described took time btw. I’d say about 6-8 months before I was feeling the libido and again it’s a different libido

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