Transgender M2Fs don’t usually get prescribed 5ARi drugs because they wouldn’t usually come with feminising effects.
One sign of PFS in a trans woman would be increase in male like effects from the anti-androgens (they would become more masculine from further therapy with the same anti-androgens that once feminised them).
Estrodiol could make sense as treatment if we look into the line of research PFSNetwork study lead is part of - prostate cancer research. Within this research it is well documented that the body adapts to the androgen deprivation therapy and causes a new equilibrium between tissue response to hormones. The tissues themselves change (mutation).
The equilibrium is highly important for health especially in the nervous system. It is yin yang between AR and ER.
As a cure no, estrogen is not likely.
As a treatment it works well for me.