Perhaps @mdshrinkgirl can answer this question. Jim
Women get PSSD regularily, women don’t get PFS because they androgenic alopecia is a male disease. SSRIs are psrecsibed for both men and women and PSSD occurs in both
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I’ve seen cases of psf in women.
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Transgender M2Fs don’t usually get prescribed 5ARi drugs because they wouldn’t usually come with feminising effects.
One sign of PFS in a trans woman would be increase in male like effects from the anti-androgens (they would become more masculine from further therapy with the same anti-androgens that once feminised them).
Estrodiol could make sense as treatment if we look into the line of research PFSNetwork study lead is part of - prostate cancer research. Within this research it is well documented that the body adapts to the androgen deprivation therapy and causes a new equilibrium between tissue response to hormones. The tissues themselves change (mutation).
The equilibrium is highly important for health especially in the nervous system. It is yin yang between AR and ER.
As a cure no, estrogen is not likely.
As a treatment it works well for me.
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Seriously? Tell me more, does estrogen actually work for you as a treatment. What symptoms does it help
I’ve taken E on/off since 2021 and consistently for a few years now.
It helps with every symptom to some extent and some it has gotten rid of. I had extremely severe PFS and so in the past it has been insomnia, shrinkage, brainfog, prostate pain, frequent urination, loss of libido and digestive issues amongst other things.
When E is working my brain works extremely well, I feel a deep connection to life and everything is better including how I look.
Unfortunately I’m very susceptible to changing response to hormones, so it’s hard to maintain all the good effects consistently, although I am for the most part consistently 70-80% better than before E.
I don’t respond as one would expect to E. I get both some female typical effects and also some male typical effects…
It certainly feels like a mutation; the actual response of tissues is all off and different.
If I stop E or increase T then I’m back to PFS nightmare as expected. The response to T is very unusual to say the least
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Regarding the hypothesis that guy makes. His opinion keeps changing and so it seems more experimental and a working draft than anything else. I’m not part of it but I hear it’s basically ran like a dictatorship and he takes advantage of vulnerable people for his own benefit.
The theory now includes mifepristone. Some limited improvement is also expected based on mutation theory for PFS. It has even been used in research for CRPC with limited success.
If you’d like to read about a risky approach and also a more realistic rational why this could work take a look at Bipolar Androgen Therapy and understand why that can work. I of course want to believe but wanting to emotionally and seeing the evidence are two different things. BAT would be slightly different anyhow, it usually would involve extremes in testosterone levels to shock the mutation and to destroy it.
As treatment estrogen alone can do multiple things including reducing testosterone levels to castrate, it can bind to ER which is likely underexpressed in tissues with AR overexpression and also it can bind to mutations. All of this can create an environment that meets the new equilibrium needs and ultimately treat some PFS symptoms in theory. There are many questions that come from this, such as do we want to relieve symptoms at the risk increasing the growth / spread of the mutation.
I don’t recommend taking risks.
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I’ve often noticed that some of the symptoms we have , are similar to women going through the menopause (dry skin, heat changes , severe insomnia , palpitations , anhedonia etc)
Of course this happens because their estrogen crashes …. I’m sure estrogen has something to do with it ……
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It is not a male disease. Female pattern hairloss is caused by the exact same thing as male pattern hairloss. Anyone who knows my story- I have entirely disintegrating skin and cannot stand by a sunny window ever again/ knows women can get PFS. please do not spread misinformation. I’m going to die of skin cancer because of these medications. I have not found anyone whose connective tissue was destroyed by minoxidil and dut/fin to that level, if anything these drugs are even more dangerous to women.
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I’m very sorry to hear that. Out of curiosity, is this a story you’ve shared on this forum?
That’s very interesting, thanks for sharing.
Thanks for sharing the information. Curious - and dangerous - stuff going on out there.
Your experience is insanely valueable to me.
I have taken a few weeks of high dose Exemestane back in 2015 in an attempt to boost my T, which it did.
However, almost ten years later I still suffer from low E symptoms which are very similar to PFS symptoms.
What E protocole has made you feel better ?
What symptoms do you have?
Extreme fatigue
Irritability
No libido or lust, just the ability to get hard when I see or smell a vagina
Flat muscles
No will to do anything
No pleasure listening to music
Can you go to the gym? Do you have strength?
I had a severe crash with clomid
Can’t go to the gym, can’t get a pump.
My muscles burn like crazy after 3 reps.
Currently 2x Estradot 100mcg patches applied twice weekly.
In the past I used estrodiol valerate vials and injected 10-20mg per week.
Both these taken as monotherapy i.e. with no other hormone.
The suppression of androgens from high doses actually helps a lot with the symptoms.
Thank you for your reply.
I just received my 2% estradiol cream.
Applying one full pump would provide 20mg estradiol, of which probably 2mg would be absorbed.
Would you advise applying that dose daily and see if symptoms improve or shocking the body with a higher dose less frequently ?
I was also planning on applying testosterone simultanously but will try estradiol on its own first.