Did you ever try the higher dosage of Align probiotic the 5x or 5 billion dosage?
I forget if you live in the states. I think its only available in the US and Canada.
It might be something to consider.
I think there could be a scenario for this, but some might need to pop this like candy to overcome a deficit.
Previously, in vitro studies with human dendritic cells suggested that promotion of retinoic acid metabolism by B. infantis was a key regulatory feature of this bacterium [21].
All-trans-retinoic acid (atRA) plays crucial roles in shaping intestinal immunity.
Bhattacharya et al. show that, in the context of colon cancer, microbiota induced intestinal inflammation alters atRA metabolism, leading to a colonic atRA deficit and exacerbation of colon
carcinogenesis. atRA supplementation
ameliorates colon carcinogenesis in a
CD8+ T cell-dependent manner.
How vitamin A and gut microbiota regulate the intestinal immune system
This is a line from one of the researchers of that study^
“When there is an infection or dysbiosis in the gut microbiome more RA is produced that results in a higher antimicrobial activity that can kill gut bacteria.”
This is seperate,
for the first time, a study suggests that gut microbes can help rebuild the human immune system .
“ The parallel recoveries of the immune system and the microbiota , both of which are damaged and then restored, gives us a unique opportunity to analyze the associations between these two systems ,” says study co-senior author Jonas Schluter.