Severe Acne in Female Patients Treated with Isotretinoin is associated with Dysbiosis and its Consequences
# Antidepressant treatment modulates the gut microbiome
Moreover, a recent in vivo study showed that SSRIs modulate the gut microbiota composition, an effect that may be related to in vitro antimicrobial properties of SSRIs [16–20].
This is a long term acne.org members recent test results from gi map. (im sure he wont mind)
He took a 3 month course of Accutane in 2007.
Has anyone else tested using GI map? it is expensive unfortunately. I myself am waiting on results from Viome (the supposed most advanced GI testing, Mayo Clinic has even recently collaborated with them)
On Gi Map,
This is the only FDA cleared DNA test for gastrointestinal microbes available. In contrast to molecular methodologies used by
other laboratories, this method was not developed in-house. Independent clinical validation data on the
method used by Diagnostic Solutions Laboratory shows that the test is reliable and reproducible. These
added quality aspects are novel and give the clinician additional confidence in DNA analysis, not
available elsewhere in the integrative and functional medicine market.
It really seems a plausible idea, to be fair.
I remember an user in here who was called brongfogboy who really got better after a fecal matter transplant - you also have a shit load of guys getting better with fasting, tackling the microbiome with foods or probiotics like lactobacilus reuteri.
This is what I like to do, or sort of how I think and look at things. I think its only a matter of time.
Its maybe not so simple atm, but Its the hottest topic in research and the medical field.
This is a life issue to me. Not a drug issue. They are linking bacteria with everything from neurodegenerative diseases like alzheimer’s and Multiple sclerosis, to metabolic disease and cancer.
oh and btw xenobiotic metabolism and drug side effects as well.
Example,
Viome’s Research Reveals Gut Microbiome Activity is Key to Understanding Why Different Individuals Can Have Opposite Blood Sugar Responses to the Same Food
Eventually it might read,
Viome’s Research Reveals Gut Microbiome Activity is Key to Understanding Why Different Individuals Can Have Opposite Drug Responses to the Same Drug
obviously diet isnt enough for some, and looking at his picture antibiotics probably isnt the answer either. Accutane can function like an antibiotic and destruction of the microbiota might be how that happened in the first place.
Isotretinoin treatment reorganizes dermal microbiome in acne patients
Publish date: January 24, 2019
Systemic isotretinoin and antibiotic treatments in acne patients precisely caused variations in the microbial floras of several sites of the body, while isotretinoin was commonly more responsible than antibiotics. Knowing that alterations in the microbial colonization of the flora regions may preceede infectious disease and bacterial resistance, treatment options and follow-up procedures in acne vulgaris should be carefully determined to reduce the risk of destruction of the microbial flora.
I had almost an immediate positive reaction to my very first f. transplant where I felt amazing the entire following day. I was never able to recreate it again despite multiple transplants from the same donor, and even another donor.
I’ve seen youtube videos of people reporting the same positive response on the first dose and not having it again afterward. I reported in that original post where I spoke about the f. transplant that the results did not last and I was/am not cured.
Couple thoughts on this based on experience and some studies.
They do say most Fecal transplants seem to be transient, also that freeze dried oral fecal capsules are nearly as effective as rectal delivery. I think the dosage was about 40 capsules at once for one of the studies I looked at.
I wonder if that initial response you got was the immune system being stimulated.
Based on the above test results posted here, im not so sure a person would want to increase the bacterial load by adding more bacteria to the lower gi tract, rather this is something that needs to be kept in check. They say the lower gi tract is healthier when it harbors diversity. (Probably because it acts like a dumpster for waste, a person wouldnt want this waste recycling.)
Where is bacterial diversity a bad thing? absolutely everywhere else outside of the lower gi tract.
Heres a study. For some reason a fecal transplant had no effect.
Gut bacteria influence the birth of new brain cells in mice
The team gave mice a combination of five antibiotics for seven weeks – an extreme treatment regime that would not be used in people. The researchers then looked at each mouse’s hippocampus, the area of the brain where neurogenesis takes place. They found around 40 per cent fewer newborn brain cells in mice given antibiotics than in untreated mice. The treated mice also performed worse in memory tests.
Restarting neurons
In another experiment, Wolf and her colleagues showed that it was possible to re-establish neurogenesis by giving antibiotic-treated mice a probiotic or making them exercise, something that is known to enhance neurogenesis in people. Surprisingly, transplanting faeces from an untreated mouse to repopulate the gut of a treated animal had no effect.
Heres the real study.
Ly6Chi Monocytes Provide a Link between Antibiotic-Induced Changes in Gut Microbiota and Adult Hippocampal Neurogenesis
Highlights
Antibiotics decrease neurogenesis and cognitive function
Probiotics or exercise rescues neurogenesis and cognitive function
Ly6Chi monocytes are crucial for brain homeostasis
