Estrogen Effects Androgen Receptors

General Discussion
#1

I’m not saying this is true for all of PFS sufferers… Though I know myself am suffering from low testosterone and relatively high estrogen.

Estrogen: Side Effects

That said, we males only need small and youthful amounts of estrogen for optimum health. The overabundance of estrogen in middle and old age is simply a bad dream. Here are just a few of the nasty things estrogen can do to us:

Decrease testosterone production. (It binds to testosterone receptors in the brain that signal for the body to produce more testosterone.)
When estrogen binds to an androgen receptor it does not activate that receptor. Testosterone, of course, activates testosterone receptors so they do what they are supposed to do. Estrogen leaves them inert and lifeless.
Displaces testosterone in androgen receptors throughout the body. Your free testosterone is basically “all dressed up with nowhere to go”.
Perhaps worst of all, high estrogen levels causes your body to make fewer and fewer androgen receptors. This is bad, very bad.
In males, increased estrogen is associated with increased blood clotting, narrowing of the arteries and heart disease.
It increases SHBG, the protein that binds to testosterone. This decreases free, “bioavailable” testosterone that is usuable by the body. NOTE: You should also read my section on Free Testosterone. Losing Free Testosterone is a very serious issue for us males.
The erectile muscles at the base of the penis are packed with testosterone receptors. As testosterone decreases and estrogen displaces testosterone, these muscles slowly atrophy leading to erectile difficulties.
Estrogen is increasingly associated with long term prostate issues including cancer.

#2

please give study sources.

#3

You really need to read the forum properly. Everything that you post has already been posted.

#4

Tim , when your feeling worse and worse everyday. It’s easy to find answers, you dont go looking on a forum full of theories…I’m just trying to find facts. Alot of what we are suffering is low cortisol and high estrogen symptoms

#5

There is about a hundred threads on estrogen and cortisol. Why not add to one of them, or see what other members have written about it. Propecia help has been round since 2006, all topics have been covered, twice.

#6

well explain this? I’m not saying its the root cause but it seems a bit coincidental and i know if this was the case it’d be cured by now. I totally believe its caused by chain of hormonal systems. Again im not a bloody scientist or think i am for reading a wikipedia article.

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Low Cortisol - In Bold my Symptms

continuing hypothyroid symptoms with a high free T3
[b]shaky hands; shakiness[/b]
diarrhea

bad palps
higher heart rate
pounding heart
feeling of panic
weakness
inability to handle stress
inability to handle interactions with others
inability to focus
rage or sudden angry outbursts
emotionally hyper sensitive
overreacting
highly defensive
feeling paranoid about people or things
exacerbated reactions to daily stress
no patience
easily irritated
mild to severe hypoglycemic episodes
nausea in the face of stress
taking days to recover from even minor stress
taking days to recover from a dental visit
flu-like symptoms
headache
all over body ache
super-sensitive skin
extreme fatigue
scalp ache
hyper feeling
jittery
clumsy (drop things, bump into things)
confusion
suddenly feel extremely hungry
low back pain
dull
cloud-filled head (happens when this patient is due for a next cortisol dose)
jumpiness
muscle weakness
“air hunger”
dizziness
light headedness
motion sickness
coffee putting patient to sleep
vomiting even running up the slightest incline
almost passing out every time patient gets up
dark circles under my eyes VERY COMMON WITH SUFFERERS
waking up in the middle of the night for several hours
difficulty falling asleep
frequent urination
IBS symptoms
worsening allergies

High Estrogen

Low sex drive
Impotency/erectile dysfunction
Infertility
Gynecomastia, or “man boobs”
Weight gain
Enlarged prostate
Prostate cancer
Testicular cancer

Low Testosterone

Decreased sex drive
Erectile dysfunction
Reduced energy level
Reduced strength and endurance levels
Sleep problems
Emotional problems including sadness, irritability, difficulty concentrating, and depression
Increased breast size and tenderness
Decrease in the amount of body hair
Decreased penis or testicle size
Loss of muscle mass

#7

Judging via previous blood work also. Maybe we all had a hormonal imbalance or Low Androgens to being with!

#8

Why do we feel shit in the morning??? coritsol is at it’s highest! and we are suffering from low testosterone.

#9

Low Aldotesterone…Hmmmm? is it all related some how.