Endocrine disrupting activities of the flavonoid


Dietary plant flavonoids have been proposed to contribute to cancer prevention, neuroprotection, and cardiovascular health through their anti-oxidant, anti-inflammatory, pro-apoptotic, and antiproliferative activities. As a consequence, flavonoid supplements are aggressively marketed by the nutraceutical industry for many purposes, including pediatric applications, despite inadequate understanding of their value and drawbacks. We show that two flavonoids, luteolin and quercetin, are promiscuous endocrine disruptors. These flavonoids display progesterone antagonist activity beneficial in a breast cancer model but deleterious in an endometrial cancer model. Concurrently, luteolin possesses potent estrogen agonist activity while quercetin is considerably less effective. These results highlight the promise and peril of flavonoid nutraceuticals and suggest caution in supplementation beyond levels attained in a healthy, plant-rich diet.

Stay away from ANY flavonoid.


Burning scalp headaches brain fog - inflammation the cause?
Warning about *dark* chocolate/cocoa/cacao (or foods containing high amounts of 5ar inhibiting flavonols)!

Let’s you wonder if going carnivore might be the way to go…



But… every vegetable and fruit has flavanoids? Am i missing something…

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The flavonoids in foods are in extremely small quantities. I got the PFS with Rutina that hydrolyzed is transformed into Quercitin. Well, this substance in high-dose is strongly anti-androgenic:

Flavonoids are dangerous..