Interesting
[youtube]http://www.youtube.com/watch?v=l0XRihHHEQU[/youtube]
can we use Nigella sativa for acetylation. Please read
Dr. Arafat and her co-workers also found that thymoquinone caused “epigenetic”
changes in pancreatic cancer cells, modifying the cells’ DNA. She explains that
these changes involve adding acetyl groups to the DNA structure, specifically to
blocks of proteins called histones.
This “acetylation” process can be important for genes to be read and translated
into proteins. In this case, it could involve the genes that are key to initiating
programmed cell death. “We looked at the status of the histones and found
surprisingly that thymoquinone increased the acetylation process,” Dr. Arafat says.
“We never anticipated that.” At the same time, adding thymoquinone to pancreatic
cancer cells reduced the production and activity of enzymes called histone deacetylases
(HDACs), which remove the acetyl groups from the histone proteins, halting the gene
transcription process. Dr. Arafat notes that HDAC inhibitors are a “hot” new class
of drugs that interfere with the function of histone deacetylases, and is being
studied as a treatment for cancer and neurodegenerative diseases. Finding that
thymoquinone functions as an HDAC inhibitor, she says, “was very remarkable
and really exciting.”