Calling for Study Participants for First Molecular Level PFS Study EVER ********************

[solonjk]

@Second Amendment

Solonjk, the guy who convinced several members here that PFS was a case of prostatisis that only a Greek doctor could cure, duping PFS sufferers into wasting thousands of dollars on this scam artist whom he still defends…then goes off and deletes all his posts. Yup, I want to model my recovery protocol after him.

I am sorry i should have forwarded everyone to awors penile skin sensitivity test and ignore every mainstream doctors approach to treating the prostate(the organ for which finasteride was originally designed) and then look into hormones.

My mistake

I forgot that awor or maybe you (awor 2?) is a top harvard scientist and i am a layman that only happened to attend 5 years of med school before i got jumped by finasteride and had to go around the world on a research tour spending thousands of euros out of my pocket, whilst you and man others here just sat in the forum and received all sorts of info for free and now you can judge and piss on people.

Too bad, i should have followed you route and start on judging everything one does.

By the way, have you tried awor’s dog anesthetics to demethylate your hidden dna sequences too?

I am also waiting for the blockbusting!!! reports from this research from some unknown “scientists” in some secret university that only awor managed to locate and despite Cambridge professor’s Hughes report (an expert on androgen insensitivity) about the impossibility of post-finasteride 5-ar II blockage epigenetically - he actually laughed on that- you keep on trying to convince people to chase ghost diseases and raise money into checking why there is insensitivity in their penile skin.
Keep people’s hopes up for a few more years, but in the meantime don’t be surprised when solid evidence comes out from research about the post-finasteride prostate and urogenital problems.

[Lincoln28]

@solonjk

@Second Amendment

despite Cambridge professor’s Hughes report (an expert on androgen insensitivity) about the impossibility of post-finasteride 5-ar II blockage epigenetically - he actually laughed on that-

More detail, or link to discussion please?

[Airborne]

This is starting to make since P450/CYP3A4 and more controls/regulates the actions/metabolism any drug/medication has on our body. This could explain the reason why some of us build up a tolerance to certain things (ie PDE5 inhibitors). I am pretty new to this site and I can’t believe the amount of arguing and disrespect that goes on. We really need to focus on the reseach, if people would put there wasted time posting argumentive things towards reseach, we could be alot futher than where we stand right now. I think this tunnel is getting more light to it. Thanks eveyone

[fin2005]

Hey solonjk: u mad bro?

P.S. thanks for deleting your entire post history. Now we cant edit our posts anymore.

[Oscar]

@Airborne

This is starting to make since P450/CYP3A4 and more controls/regulates the actions/metabolism any drug/medication has on our body. This could explain the reason why some of us build up a tolerance to certain things (ie PDE5 inhibitors). I am pretty new to this site and I can’t believe the amount of arguing and disrespect that goes on. We really need to focus on the reseach, if people would put there wasted time posting argumentive things towards reseach, we could be alot futher than where we stand right now. I think this tunnel is getting more light to it. Thanks eveyone

Yes, thankfully awor has got some scientists interested in the problem and they are checking the genes of the enzymes that finasteride has effected. Maybe this will show a marker for the cause of this problem. As far as enymes go, what types of diseases can be associated with them? I can only think of three 1. An insufficiency (ie 5aR destroyed) 2. Too much (ie overactive CYP4503A4 /SULT2A1 can cause hypogonadism viewtopic.php?f=27&t=5589 for example).

[Airborne]

Oscar,
I’m thinking exactly along the lines of what your thinking. I personaly dont think are 5aR is destroyed it’s just not being expressed the way its should be. Is there any therapeutic approaches that you are aware of that can work in either direction ( ie enzyme activation/deactivation and so forth)?

[golf]

@Airborne

Oscar,
I’m thinking exactly along the lines of what your thinking. I personaly dont think are 5aR is destroyed it’s just not being expressed the way its should be. Is there any therapeutic approaches that you are aware of that can work in either direction ( ie enzyme activation/deactivation and so forth)?

yes
onlinelibrary.wiley.com/doi/10.1111/j.1365-2826.2011.02152.x/abstract

en.wikipedia.org/wiki/Allopregnanolone

[Airborne]

Sorry for the stupid question, I asked before I searched. I’m being lazy.

[notworthit]

@Oscar

@Airborne

This is starting to make since P450/CYP3A4 and more controls/regulates the actions/metabolism any drug/medication has on our body. This could explain the reason why some of us build up a tolerance to certain things (ie PDE5 inhibitors). I am pretty new to this site and I can’t believe the amount of arguing and disrespect that goes on. We really need to focus on the reseach, if people would put there wasted time posting argumentive things towards reseach, we could be alot futher than where we stand right now. I think this tunnel is getting more light to it. Thanks eveyone

Yes, thankfully awor has got some scientists interested in the problem and they are checking the genes of the enzymes that finasteride has effected. Maybe this will show a marker for the cause of this problem. As far as enymes go, what types of diseases can be associated with them? I can only think of three 1. An insufficiency (ie 5aR destroyed) 2. Too much (ie overactive CYP4503A4 /SULT2A1 can cause hypogonadism viewtopic.php?f=27&t=5589 for example).

If we were dealing with the over expression of cytochrome P450 (CYP)3As and hydroxsteroid sulfotrasferase and the resulting purported metabolic deactivation of androgens we would not be seeing the widely reported continued action of androgens (continued hair loss, facial hair growth {unabated}, and even acne in some who have never had any). It is also a bit of a stretch in my opinion that enzymes that were initially in short supply (fair enough), are now, years later still being over expressed. I appreciate that you connected the dots already existing in the literature.

[tim1911]

@notworthit

It is also a bit of a stretch in my opinion that enzymes that were initially in short supply (fair enough), are now, years later still being over expressed.

??? Isn’t that what this whole thread is about? Changes that have occurred due to finasteride use that haven’t changed back.

[notworthit]

@tim1911

@notworthit

It is also a bit of a stretch in my opinion that enzymes that were initially in short supply (fair enough), are now, years later still being over expressed.

??? Isn’t that what this whole thread is about? Changes that have occurred due to finasteride use that haven’t changed back.

Overexpression years later ? Remember, it is not the same as saying the under/over expression of a gene.

[tim1911]

I guess we will find out when airborne does his testing and when awor does his.

[notworthit]

@tim1911

I guess we will find out when airborne does his testing and when awor does his.

Indeed ! I still believe the liver is the central player; we already know that Isotretinoin messes with androgen receptors, so I am sure Awor is on to something too.

[Oscar]

@notworthit

@Oscar

@Airborne

This is starting to make since P450/CYP3A4 and more controls/regulates the actions/metabolism any drug/medication has on our body. This could explain the reason why some of us build up a tolerance to certain things (ie PDE5 inhibitors). I am pretty new to this site and I can’t believe the amount of arguing and disrespect that goes on. We really need to focus on the reseach, if people would put there wasted time posting argumentive things towards reseach, we could be alot futher than where we stand right now. I think this tunnel is getting more light to it. Thanks eveyone

Yes, thankfully awor has got some scientists interested in the problem and they are checking the genes of the enzymes that finasteride has effected. Maybe this will show a marker for the cause of this problem. As far as enymes go, what types of diseases can be associated with them? I can only think of three 1. An insufficiency (ie 5aR destroyed) 2. Too much (ie overactive CYP4503A4 /SULT2A1 can cause hypogonadism viewtopic.php?f=27&t=5589 for example).

If we were dealing with the over expression of cytochrome P450 (CYP)3As and hydroxsteroid sulfotrasferase and the resulting purported metabolic deactivation of androgens we would not be seeing the widely reported continued action of androgens (continued hair loss, facial hair growth {unabated}, and even acne in some who have never had any). It is also a bit of a stretch in my opinion that enzymes that were initially in short supply (fair enough), are now, years later still being over expressed. I appreciate that you connected the dots already existing in the literature.

Thats right, use existing medical literature! Can anyone find any more disease states that relate to enzymes?

Im not actually aware of any substances permanantly altering the expression of enzymes, whether it be loss-of-function or over-expression, but I stand to be corrected on that. Either way, this will not be detected in any DNA tests as the genome is different from the phenome. The third item on the list can be caused by enzyme inhibitors and i believe might match my symptoms.

[Jeno]

I meet the requirements for the study but I guess no need for more peoples?

I hope so much. That there could be found a way. To see what has gone wrong in us.

[solonjk]

@Lincoln28

@solonjk

@Second Amendment

despite Cambridge professor’s Hughes report (an expert on androgen insensitivity) about the impossibility of post-finasteride 5-ar II blockage epigenetically - he actually laughed on that-

More detail, or link to discussion please?

call him up

or visit

[solonjk]

@fin2005

Hey solonjk: u mad bro?

P.S. thanks for deleting your entire post history. Now we cant edit our posts anymore.

sorry man… i had to

[Sorryitookfin]

Any new info on the study I’m sure I’m not the only one holding my breath for some kind of good news.I am feeling like I’m getting worse with no matter what treatment I try.

[bruins2]

can’t wait for the results good or bad!

[boston332]

Awor, after the first round of penile biopsies you made the remark that there has been something significant found there but does not explain the entire picture (paraphrasing). In light of those remarks are you still working under the supposition that there is still one underlying mechanism and you need to dig deeper or are you thinking there may be other issues at play?