Regarding fundraising the next step is setting up the not for profit. This isn’t as easy as filling out a few forms. Would have to file with the federal and state governments (assuming it will be in the US). Will take time and some legal work and it’s not a give you will be granted tax exempt status. This will be key to facilitating larger donations. No one is going to send 5k or 10k to “boston332” over the internet. Also, such a “gift” would technically be taxable. Not for profit would make donations tax deductable and make the accounting transparent. Whoever the chair of non-profit would have to arrange accounting for state and federal reporting each year.
This baffles me too. How can someone suffering this horrible disease keep away from here completely?
Chi just left the forum and he was involved in the initial penile biopsies involved in this research 
Awor are people jumping the gun here or have you found something in advance of this quote from yourself?
Also what do you think about brief recoveries, for example my brainfog resolved itself temporarily from doing intense exercise, how ever i could not replicate this the next time i did intense exercise, from manuka honey with a smf 10, however this could not be replicated and from a 24 hour fast, when i woke up the next day i was clear as a bell.
Please any thoughts?
Also any additional thoughts about why marijuana brings my libido and sensitivity back and why pde5i work for me but only when they are cycled.
Cheers
We know this and are working in that direction. The critical part here is to find someone who will represent the not for profit organization in the US from a legal point of view. The ideal candidate would have a solid business and/or legal background. If anyone matches this criteria and is interested, please send me a pm.
If gene expression is really at fault here, is this something that can be potentially passed on to future children? Any rough ideas on this subject matter would definitely help me out. God forbid I pass this gene on…
I am not sure I understand what you mean by people jumping the gun. I can say, however, that the interpretation of the results has gotten quite a bit clearer since my original post. The discovery we made is highly significant and clearly shows that we are on the right path and what the next steps must be.
This seems highly logical to me. Excercise increases androgen levels (T, DHT). We know from our user base that some of those who tried TRT, Clomid, etc. had a brief recovery from it. Even I “recovered” for about a day on high dosed TRT initially. The improvement, as we know, is seldom persistent. This fact is absolutely core to explaining our problem. What we found in the original experiment can explain that.
Another analogy is the initial “recovery” followed by a “crash”, that many of us experience after quitting fin. When we quit fin, our DHT levels come back, making many of us feel better. However, it is exactly this increase in androgens, which then overloads our system and makes us crash. This is the same story like TRT, DHT supplementation, clomid, excercise, orgasm, all of which also increase androgens.
Sorry, have no idea what you are talking about here.
Hmm, very interesting. This appears to be another example, where substances which reduce AR activation (by whatever means), at least transiently make some of us feel better. It appears that cannabinol (contained in marijuana) significantly reduces plasma DHT levels[1]. This fits into the general pattern of things we are seeing on this site, where some people are reporting feeling better from things like:
- Milk thistle (inhibits transcription of androgen responsive genes)
- Zinc and above all copper (JN et. al.) - specially copper is a potent inhibitor of 5AR
- High dosed juicing (many vegetables significantly inhibit 5AR)
Some users are even reporting feeling better by taking serious 5AR inhibitors again such a dutasteride, finasteride or saw palmetto.
Now look at the opposite, people actually increasing androgens by means of supplementation (T, DHT), clomid, heavy excercise or even orgasm. We are seeing many reports around this place that any androgen increasing activity makes people feel worse (as also stated above).
If you start putting these two facts together: increasing androgens tends to make people feel worse, reducing androgens tends to make some feel better, it should be pretty clear what is going on. I can’t spell it out right here and now, but if you read some prostate cancer research papers, and check out what happens to the AR in those prostates when patients undergo androgen ablation, you’ll have the answer. (And no, I am not saying we have prostate cancer, I am just talking about the relevant molecular behavior).
The basic underlying mechanism we found in the penile skin experiment provides a very solid basis for explaining the above. I hope to be in a position to get into more detail within a couple of months.
[1] Evidence that the effects of methadone and marihuana on male reproductive organs are mediated at different sites in rats biolreprod.org/content/20/5/1039.full.pdf
Unfortunately some of the studies I’ve read show that epigenetic changes may be inherited. The one that comes to mind was the Dutch study during WW2. Sorry I don’t have the link right now to reference but the Dutch have actually done quite a bit of studies in this area if you google scholar it. I don’t think we can rule out the possiblity from what I’ve seen but that’s getting the cart a bit ahead of the horse right now. Let’s see the results of the study and get a better idea of what’s been changed/altered before we go down that road.
Yes good answers awor and believe me i am behind you so please don’t take these questions in a challenging way, that is if you did.
What are your thoughts on why we gain tolerances, for example i used zinc a while back and popped boners all day, yet have been unable to replicate this.
Also i mentioned pde5i tolerance, i can use one brand (viagra, cialis, levitra) for a max of 2 days in a row but after that nothing. Yet if i cycle through them i can achieve on going success.
This seems to be trend on the forum.
Also marijuana as i posted brings back my sensitivity and as you posted via the study that this was due to a reduction in androgen’s.
So that makes me think of the question do androgen’s/ar activation have very little to do with penile sensitivity, if reducing them (via marijuana) can increase sensitivity?
No, not taking any offense at all 
The concepts I am talking about is not at all straight forward to understand if you don’t have a background in molecular biology. When the time comes, I will write it up in a way that is easier to digest.
In any case, I didn’t manage to get my point across. The fact that reducing androgen activation makes people feel better has a lot to do with the problem and with the AR. If the body “senses” that there is too much androgenic action going on, it will counter react to that. It is the combination of this “over-sensing” and a counter reaction, which is presumably causing our problem. In other words, by reducing androgen activation, you are reducing the counter reaction, thereby feeling better. Inversely, by increasing androgens, you are increasing the counter reaction, thereby feeling worse. The counter reaction occurs with a delay, which is variable from person to person. This, btw, is known molecular behavior and occurs in many settings inside of our body, not just related to androgens.
Indirectly related to this, I find your comment about viagra interesting.
Im wondering if the experiment from the penile skin will tell why my balls are always aching it comes and goes but it’s like torture.my penis being smaller and shrunken drives me crazy .is this a result from the downregulation and if it can be straighten out will it relieve these bad symptoms physical and mental?just curious so much seems damaged. I want my old junk back with no pains that would make me feel like a man again.tired of pain.Plus our fertility can that be fixed I know for some of us our semen is less,discolored or clumpy.I wanted another kid afraid I might not be able too.I don’t want to get ahead of ourselves but I wonder if it’s all related?
What about people like myself who gain crippling sides on the drug and dont change/no improvement in symptoms, even briefly at all after quitting, it was like the dht never returned for me?
I think we need a new thread called “Ask awor” 
^ What did the penile skin experiment check for? Is this what is being published as research? And has the gene test study been completed yet? Do they have any results from that? thanks
With this basic principle in mind, is there a best practices approach to what we should and should not take? Is there any harm in taking something that makes us feel better, but subsequently decreases androgen activation? Or is this like a proverbial step ladder that helps our bodies slowly acclimate from a strong androgen inhibitor (Fin/Proscar/Dut) to a weaker one (MMT/Zinc/Copper/Marijuana…etc) to no inhibitor?
Just read this thread. Both are being published.
I realise that it must of been a microarray test with the skin biopsy - to discover ‘once and for all’ if androgens are working. So will that mean the future funding is for a some kind of better microarray test of gene expression? What other kind of tests is there?
And could the DNA saliva results still tell us something?
I was thinking that myself. I was also thinking that an effective therapuetic approach (one which has pretty good anecdotal success) would be to continue heavy resistance training even when it makes you feel worse… until your body no longer has the counter reaction. We got into this mess by telling ours Androgen Receptors for weeks/months/years that the androgens were harmful by significantly decreaing them. Maybe we have to tell them for weeks/months/years that the androgens are not harmful (which would mean us feeling like shit for that amount of time, making it even more difficult.) That’s what the famous mlevyholden did in his one post wonder, and it took him 10 months to get better (used proscar for 8). Others have had success with long term weightlifting–persisting even though it hits them hard. Excuse me if anyone thinks I am straying away from molecular biology and going into a mind-body direction, I am not. But I understand this is a topic for another thread.
EDIT-to make this post more on topic. Resitance training has been shown to affect gene expression, but I could not find an article about resistance training and gene expression on the AR level.
Solonjk was bedridden for an extended period of time after trying to do this. I think it happened to him once, he recovered, then he tried exercise again and he was left in bed for months. I would research it better but his post history is gone.
There are also other reports of crashes attempting this. It’s the same in principle as pushing sexual function (i.e. masturbating) until the body responds right. The problem is that in many cases it simply doesn’t and pushing this approach can cause a crash leaving the person with more problems than when they started. It doesn’t seem to be this way for everyone, however the effect happens so often that it cannot be ignored.
Solonjk, the guy who convinced several members here that PFS was a case of prostatisis that only a Greek doctor could cure, duping PFS sufferers into wasting thousands of dollars on this scam artist whom he still defends…then goes off and deletes all his posts. Yup, I want to model my recovery protocol after him.
Awor by jumping the gun i mean people trying to design recovery protocols before the problem has been found, i mean if the problem was found you wouldnt need 20-40k for further investigation, right?
Also please have a go at answering this if you have time… thanks.
In regards to the above quote are you able to tell us anything about the results of the neurosteroids that were tested, as myself with severe brain fog a disconnection between brain and body (penis included), muscle twitches but have muscle and can put on muscle,
feels like my problem is to do with the CNS.
Awor said that substances that reduce androgenic action make us feel better in the short term and worse in the long term (110% correct from my experience.) So, would increasing androgenic action make us feel worse in the short but better in the long term? i.e. months or even years of elevated androgens. We got into this mess by inhibiting our DHT by 50-70% for week/months/years. When we stopped the inhibition, our androgen receptors did not take a liking to it and the cells changed function. Would increasing DHT for weeks/months/years get our androgen receptors working like they used to? Undoubtedely, with many setbacks along the way. Many people kept taking fin even tho they felt it was having negative effect on them. (Merck also helped to persuade us to keep going). So, once someone feels like shit from increasing androgens with something like creatine, we all stop and say it’s not a good idea? The reasoning doesn’t seem to make much sense. You put stress on the cell, it either adapts or dies. Our cells adapted to low DHT levels and it fights when androgens get elevated. Wouldn’t continued stress to the cells, (raising androgens for an long period of time) adapt the cells back to the way they were before? Just a thought, perhaps further discussion belongs in the Texas Sharpshooter fallacy section…I mean theories section.
Dustin had ongoing success from the beginning with high dose testosterone. Dury recovered when he took his test. to about 1100 via clomid. Neither of them said anything about getting worse before they got better. Jurys been gone about a year now.