Biologist discusses PFS (Dr Ayers)

Tpenf · May 25, 2018, 6:46am

very interesting… thanks

bluecloud87 · May 25, 2018, 6:46am

I saw this the other day. It’s interesting that he mentions Dexamethasone as a treatment for PFS, although it seems he has done so based purely on anecdotal evidence from this forum, which is a shame as i got very excited about the possibility that he knew something that we didn’t. It’s pretty clear that he has been browsing here. Anyway, it’s great to see a Biologist with such impressive credentials taking interest in our problems. I am convinced that our symptoms stem from chronic inflammation or autoimmune issues rather than androgen resistance/ hormones so this was very interesting to see.

Overall though - the writer is claiming that through ‘cooling inflammation’ in our bodies we will not only solve our sexual issues but also cure baldness. This unfortunately leaves me very skeptical.

Lincoln28 · May 25, 2018, 6:46am

I did’nt find this, but full credit to whoever did.

Lincoln28 · May 25, 2018, 6:46am

Leave that aside. Besides were not looking for a cure for baldness.

The guy is giving his own angle. The more docs do this, the better…no?

bluecloud87 · May 25, 2018, 6:46am

I know were not, i couldn’t care less about my hair - im just saying. Believe me i was very happy to see this when another member showed me. I have actually been taking pharmaceutical grade fish oil and probiotics for some time now and dexamethasone is next on my treatment plan. So to suddenly see a Biologist that has held posts at Harvard amongst other places advocating the use of all three of those is great.

Tpenf · May 25, 2018, 6:47am

Quote from Dr Ayres in the comments…

“I would not use a 5-alpha reductase inhibitor unless the alternative was surgery or death.”

bluecloud87 · May 25, 2018, 6:47am

I wish he would answer the questions about dexamethasone and others.

Despo111 · May 25, 2018, 6:47am

I have a joint issues, so I took dexa injections for that in 2001. or 2002. while still on propecia. I noticed great improvement, but it last only couple of days. But I am off propecia for couple of yrs. Maybe it worth to try I again now.

Desperado.

spstriken · May 25, 2018, 6:47am

I wonder where benefits of DM come from? Being as anti-inflammatory or being as immunosuppreassant?
To me look like bieing AF since some members report improvements after using NSAIDs.

Despo111 · May 25, 2018, 6:47am

I think its antiinflamatory, because corticosteroids have very strong antiinflamatoric effect. But corticosteroids are also a hormons. So all comments on this subject are welcome.

Laters, Despo.

Tpenf · May 25, 2018, 6:48am

coolinginflammation.blogspot.com/

Another post by Dr Ayers…

[Size=4]Low Dose Naltrexone
A side effect of high dose Naltrexone (e.g. 50 mg/d) is hair loss. Low dose Naltrexone (e.g. 1 mg/day, taken at night) appears to stimulate hair production and it may reverse the effects of Finasteride, since LDN improves libido.
[/size]

boston332 · May 25, 2018, 6:48am

This guy looks like he’d be great to have on our research team with his all his bio background and the fact that he has theorized a PFS treatment. Not to mention he’s in San Deigo so maybe he could work somehow with Goldstein’s PFS guys if something looked promising.

Any ever have any contact with him? Someone should at least email him about the conference no? Maybe he’d be interested in contributing.

bluecloud87 · May 25, 2018, 6:48am

He seems to be more focused on treating ‘baldness’. He didn’t reply to a single comment in relation to finasteride side effects.

boston332 · May 25, 2018, 6:48am

After more careful reading looking like he mean reversing the effects of Finasteride while taking the drug and he’s not talking about PFS.

For some reason I couldn’t edit my above post? Maybe that feature has been removed due the recent abuse of it.

bluecloud87 · May 25, 2018, 6:48am

It’s a shame you need a compounding pharmacy to sort out a low dose version. Otherwise it’s 50 mg only:

unitedpharmacies.co.uk/search.php?mode=search&page=1

Luckfax · May 25, 2018, 6:48am

I agree it’s good he’s taken interest, but Naltrexone has bee tried by a few members without real benefit. Plus he’s singling in on the sexual side effects only.

I don’t think the fact he’s been to Harvard or whatever matters much as there, as we all know there have been other highly educated medics like Jacobs who can’t grasp this. He also seems to approach things from a slightly quacky anti-aging angle.

Plus it’s even dafter if he’s talking about reversing side while on the drug, anyone with half a brain stops when the sides become intolerable rather than start taking even more pharmaceuticals to offset them.

toadstool · May 25, 2018, 6:48am

Because Jacobs, shippen, and crisler have sooooo much success curing pfs already…

Luckfax · May 25, 2018, 6:48am

Er, yes that’s kind of my point.

toadstool · May 25, 2018, 6:48am

Well since I cant edit my posts now… because of certain people…I meant too imply that its not quackary…

Oscar · May 25, 2018, 6:51am

Wow! the guy can even cure rheumatoid arthritis !

blogger.com/comment.g?blogID=196334975274806517&postID=5083698792519085609

Hi Dr. Ayers,

Like many people I found your blog while researching my own condition and have learned a lot from it. I was recently diagosed with rheumatoid arthritis based on symptoms (joint pain and stiffness in hands, wrists and knees that came on suddenly) and weak positve anti-CCP blood test(25). But my Sed rate is low (7mm/h), rheumatoid factor is negative, CRP is also low (<.01mg/dL). I am 47, have been eating a diet that is fairly anti-inflammatory for most of my adult life, mostly veggies, very little processed foods, oily fish and fish oil, only olive oil, some gluten but way less than average American diet, no anti-biotics and good dental health. I swim 3x week and am very fit. Currently taking 10mg of prednisone while deciding what to do about treatment. It has helped my sypmtoms significantly. Rheumatolgist is suggesting MTX, but I would like to avoid heavy drugs. Do you think inflammation is an underlying problem for me despite my blood results and diet?

Thanks, Betsy

August 11, 2011 12:21 PM

Dr. Art Ayers said…
Betsy,
Your condition is obviously inflammatory (and autoimmune) with classic symptoms and response to a potent anti-inflammatory drug.

The cause of your condition was chronic inflammation (probably dietary), combined with modest injury to joints and damage to your gut flora (which reduced regulatory T cells and led to autoimmunity.) Normal and even intense exercise should result in joint damage that is fully repaired. Chronic use damage can accumulate, however, if chronic inflammation is present.

I can’t tell from your brief description where you get most of your calories. If it is not saturated fat in meat/dairy, then it is usually plant starch. The carb-based diet would tend toward higher blood sugar/insulin and higher production of reactive oxygen species… inflammation. Your diet remains your main cause of problems. Constipation would be a symptom of extreme gut dysbiosis.

As Fred indicated, gluten would be another obvious source of inflammation and disruption of normal gut/gut flora function.

Vitamin D deficiency would be another likely candidate.

All of the local treatments. heat/cold, capsaicin/menthol/castor oil, vagal stimulation postures/exercises, should give temporary relief from pain, so that you can maintain a complete range of motion. Brief use of NSAIDS may also be worth their side effects, to provide a return to normal activity.

For a permanent cure, you need to repair your gut flora, fix vit.D, fix diet and maintain exercise.

You should have no symptoms at your relatively young age, unless you have poorly managed inflammation. I think that complete relief from your symptoms should be fairly simple.
Let me know how you do.