This paper is only theorizing that such a thing may exist - it doesnt claim it does exist. Nobody that has responded poorly to trt is “believed” to have this condition.
The paper makes no mention of trt. In fact PCOS in women leads to hyperandrogenism. The guys on meso-rx are saying this would cause trt not to work because the presence of low SHBG in such an instance would cause test to convert more readily to DHT and E. But Dr Scally himself sees no reason why this should lead to trt not working.
Our main problem is that DHT has no positive androgenic effects. Quite the opposite of what the guys on meso-rx claim is ‘trt failure’ (more DHT).
Apparently balding before 30 is also very common. The paper also states:
Did we all go bald for the same genetic reason? Did we have high levels of androgenicity pre-fin? Maybe! (viewtopic.php?f=27&t=5111) But I dont see why this male-PCOS would cause our problems.