Androgen Insensitivity Syndrome

[moonman1]

I am sure (hopefully) that some form of this is being looked at by AWORs research team.

In reality, some form of AI (or some similar form) could be very possible. It is the only logical reason that I can think of that androgens do not make us better in any form. Every other male regardless of condition will have at least some beneficial side effect from raised androgens (increased libido, more erections, more muscles, more manly feelings, etc).

However, what is perplexing is that any improvements that have been made have been with messing with dopamine, adrenals, thyroid, etc…

It is interesting none the less. I have had my testosterone up to 1,200-1,800 with DHT top of the range. Recently I also had my testosterone down to 99 and I really did not notice a difference in anything now that I think about it.

Acquired androgen insensitivity may occur without AR mutations by mechanisms such as drugs including non-steroidal (flutamide, bicalutamide, nilutamide) and steroidal (cyproterone acetate), drugs that block part of testosterone activation such as 5α reductase inhibitors (finasteride, dutasteride) or estrogen antagonists or aromatase inhibitors.
endotext.org/male/male2/male2.htm\

I believe that Mew tried to contact that author, but no idea what came of it.

[sanane]

i have elevated TSH level along with low lh and low total t.

lab clearly shows how external dht proviron worked on me. i felt good mood and increased body hair.

why we try to overload DHT & T sametime with specific ratio

how to get validate/tested my body still sensitive to androgens?

[joeyt]

sasane,

did proviron releive your symptoms? how are you feeling?

[spstriken]

@moonman1

Acquired androgen insensitivity may occur without AR mutations by mechanisms such as drugs including non-steroidal (flutamide, bicalutamide, nilutamide) and steroidal (cyproterone acetate), drugs that block part of testosterone activation such as 5α reductase inhibitors (finasteride, dutasteride) or estrogen antagonists or aromatase inhibitors.
endotext.org/male/male2/male2.htm\

.

I think I have seen a some posts where people gots sides similar to us after using aromtase inhibitors.

[Lincoln28]

Found this online from

treelight.com/health/healing/Cholesterol.html

If something interferes with the production or use of testosterone or growth hormone, then the body would keep signaling for it, and the liver would keep generating it. The result would be an oversupply of cholesterol.

Hmmmmmmm…

[sanane]

@joeyt

sasane,

did proviron releive your symptoms? how are you feeling?

none of DHT or T will help you , try on thyroid & adrenal treatments, 2 years after waiting. T4 changed my life, read JN s post. he is right i think, because i felt the change with T4, i am also hypothyroid like vast majority of this forum…

[esermon]

there are some things that cannot be explained by androgen insensivity i think. 1 Why hair keep on falling to some of us if we don’t feel androgens anymore? 2 When i took the third syringe of hcg in 3 weeks i felt testosterone in every single part of my body, i needed to matsurbate at least twice a day, but the physical response was still not good, erectile dysfunction was still present nearly at the same level of before. Well those 2 situations could be due to a faint a.i. my body still feels androgens to feel libido and lose hair but not to achieve a good erection but the third one?? 3 why cialis doesn’t work on some of us (like me), my erection with or without cialis, even at the highest dosage, is almost the same, maybe it’s better of 5%, or maybe it’s really just the same.

[Enden]

@esermon

3 why cialis doesn’t work on some of us (like me), my erection with or without cialis, even at the highest dosage, is almost the same, maybe it’s better of 5%, or maybe it’s really just the same.

You need to do kegel exercises, and I recommend that you use 5 grams of L-arginine a day to boost the efficacy of PDE-5 inhibitors. It’s a precursor to nitric oxide, which increases the level of cGMP. I recommend that you use 2.5 mg or 5 mg Cialis tablets once a day, instead of large doses when needed. By doing so, cGMP will accumulate.

[bryce54]

@Enden

@esermon

3 why cialis doesn’t work on some of us (like me), my erection with or without cialis, even at the highest dosage, is almost the same, maybe it’s better of 5%, or maybe it’s really just the same.

You need to do kegel exercises, and I recommend that you use 5 grams of L-arginine a day to boost the efficacy of PDE-5 inhibitors. It’s a precursor to nitric oxide, which increases the level of cGMP. I recommend that you use 2.5 mg or 5 mg Cialis tablets once a day, instead of large doses when needed. By doing so, cGMP will accumulate.

no, you should definitely NOT NOT NOT do kegel exercises. if you goto the website, hardflaccid.org, the majority of the members have penis injuries that have caused their penises to have blood trapped in them and they have prominent veins popping out and they have numbness. sound familiar? they got the problems from doing kegel exercises trying to enlarge their penises, never touched propecia.

i do know though, in some circumstances it has helped people… however… with the limited information surrounding it and the lack of education on these problems with doctors… its not worth it imo

[esermon]

i have been doing kegel exercises for 10 days i think, but now i quit, i thought they had no dangers. About cialis and l-arginine i take 5 mg of l-arginine before bed the first day, then 5 mg of cialis before bed the third day and 5mg of l-arginine the sixth day and so on, i read on this site that u can gain tolerance to this drugs if you take them every day. now what is the truth, every day or not??

[martinM]

How many people with persistent side effects after discontinuing finasteride developed problems from kegels? Please list them if you know of any.

[Enden]

@bryce54

@Enden

@esermon

3 why cialis doesn’t work on some of us (like me), my erection with or without cialis, even at the highest dosage, is almost the same, maybe it’s better of 5%, or maybe it’s really just the same.

You need to do kegel exercises, and I recommend that you use 5 grams of L-arginine a day to boost the efficacy of PDE-5 inhibitors. It’s a precursor to nitric oxide, which increases the level of cGMP. I recommend that you use 2.5 mg or 5 mg Cialis tablets once a day, instead of large doses when needed. By doing so, cGMP will accumulate.

no, you should definitely NOT NOT NOT do kegel exercises. if you goto the website, hardflaccid.org, the majority of the members have penis injuries that have caused their penises to have blood trapped in them and they have prominent veins popping out and they have numbness. sound familiar? they got the problems from doing kegel exercises trying to enlarge their penises, never touched propecia.

i do know though, in some circumstances it has helped people… however… with the limited information surrounding it and the lack of education on these problems with doctors… its not worth it imo

Kegel exercises are safe, and everyone on this board should do them regularly! It has improved my condition. When I began doing them, I could hardly contract the muscles, but they’re a lot stronger now. I’m talking about contracting the muscles for 15 seconds, then relax for a few seconds, and repeat as much as possible. Naturally, the penile muscles are built through masturbation, and contracting the muscles like I suggested is normal during masturbation, because it increases the sensitivity.

[Enden]

@esermon

i read on this site that u can gain tolerance to this drugs if you take them every day. now what is the truth, every day or not??

Bullshit. By doing as I said, cGMP will accumulate. That’s the purpose of these pills. However, if your testosterone/estrogen ratio is bad, the pills won’t work. I believe that everyone with PFS has a problem with it. Dopamine plays a role as well, but that’s an easy fix with Dostinex.

[martinM]

Enden, a quick search of the site reveals many anecdotal reports of members that have taken ED drugs consistently and they stopped working. If the pill works for a few days, weeks, or even months and then stops working then they develop a tolerance to it’s desired effects. You’re suggesting that the tolerance to the drugs effects can be overcome by taking more pharmaceuticals to correct hormonal or neurotransmitter imbalances.

If this is the case can you please post some scientific direction on this? There are quite a few guys who would benefit from this knowledge.

[Enden]

Like I said, the pills are dependent on a good testosterone/estrogen ratio to work. I tried 2.5, 5, 10 and 20 mg Cialis 8 months or so after I got damaged by the drug - and it didn’t do shit. More than a year later, I tried 100 mg Viagra - same thing. Since then, I’ve been working on the androgen/estrogen ratio, and I’ve had several good periods the last six months, and decided to try 2.5 mg Cialis a day again - and guess what, they worked this time! When I overdosed on Arimidex, they stopped working. This happened several times. A lot of people in the body building community have the same experience.

The problem is that it isn’t done much research in this field. I suggest that people begin to read about estrogen dominance, how it affects men, and how it’s treated. Read about prolactin and dopamine as well - how it affects the sexual function.

[Enden]

I may add that doctors says that PDE-5 inhibitors won’t work without libido, and according to my experience, it’s the testosterone/estrogen ratio that’s most important. Dopamine increases the libido as well. It decreases the refraction period, and makes the orgasms more pleasurable. DHT affects libido too, but only when my testosterone/estrogen ratio is good. At this point, DHT is explosive.

Morning erections; that’s how you know if your testosterone/estrogen ratio is good. Long refraction period tells you that the prolactin level is too high. It doesn’t matter if it’s still within the “normal range”.

If you have sexual problems, I would try this protocol:

Week 1: 0.25 mg Dostinex twice a week.
Week 2: 0.25 mg Dostinex twice a week, and 25 mg Proviron a day.

PAUSE treatment when the condition improves drastically, or quit when those 2 weeks are over. If the condition improves, don’t take another Proviron pill before it’s going downhill again - see if it improves, and if not - quit the treatment, and begin treatment with 25 mg Clomid a day for 6 weeks. Use Dr. Shippens zinc protocol to adjust the testosterone/estrogen ratio when you’re finished with Clomid, if you don’t have morning erections at this point. It’s 100 mg zinc and 3 grams of vitamin c a day. I would take everything at once, before bed. Quit treatment immediately, when you get a morning erection. Repeat the zinc protocol if you lose them again.

[esermon]

well maybe i should restart kegel exercise because i suffer from premature ejaculation (of course i didn’t have this problem before fina, it’s a side effect too). What is testosterone estrogens ratio?

[bryce54]

@Enden

@bryce54

@Enden

You need to do kegel exercises, and I recommend that you use 5 grams of L-arginine a day to boost the efficacy of PDE-5 inhibitors. It’s a precursor to nitric oxide, which increases the level of cGMP. I recommend that you use 2.5 mg or 5 mg Cialis tablets once a day, instead of large doses when needed. By doing so, cGMP will accumulate.

no, you should definitely NOT NOT NOT do kegel exercises. if you goto the website, hardflaccid.org, the majority of the members have penis injuries that have caused their penises to have blood trapped in them and they have prominent veins popping out and they have numbness. sound familiar? they got the problems from doing kegel exercises trying to enlarge their penises, never touched propecia.

i do know though, in some circumstances it has helped people… however… with the limited information surrounding it and the lack of education on these problems with doctors… its not worth it imo

Kegel exercises are safe, and everyone on this board should do them regularly! It has improved my condition. When I began doing them, I could hardly contract the muscles, but they’re a lot stronger now. I’m talking about contracting the muscles for 15 seconds, then relax for a few seconds, and repeat as much as possible. Naturally, the penile muscles are built through masturbation, and contracting the muscles like I suggested is normal during masturbation, because it increases the sensitivity.

did you even goto hardflaccid.org? they all have serious penis problems and no libido and A LOT of them got it from kegel exercises gone wrong. since this phenomenon is going on, and there’s not really any science or literature prompting people how to do properly without injury… you are taking a risk by doing it. like i said, it MAY help people if you do it right or know what you are doing or don’t over do it… but you’re taking a risk none the less since this stuff isn’t researched and not really well known. please don’t promote stuff on here that may bring devastating side effects to someone else. for people that are in bad shape, and then if they overdo these kegel exercises desperate to get better, they may do more good than bad.

[esermon]

@bryce54

did you even goto hardflaccid.org? they all have serious penis problems and no libido and A LOT of them got it from kegel exercises gone wrong. since this phenomenon is going on, and there’s not really any science or literature prompting people how to do properly without injury… you are taking a risk by doing it. like i said, it MAY help people if you do it right or know what you are doing or don’t over do it… but you’re taking a risk none the less since this stuff isn’t researched and not really well known. please don’t promote stuff on here that may bring devastating side effects to someone else. for people that are in bad shape, and then if they overdo these kegel exercises desperate to get better, they may do more good than bad

Everything is so confusing!! Doing something that is not 100% safe is like taking propecia, not more not less, you just need to be lucky. Are you sure they used to do kegel exercises and not something else like jelquing or stretching? I think they can bring sexual problems as well, can’t they?

[Enden]

@bryce54

did you even goto hardflaccid.org? they all have serious penis problems and no libido and A LOT of them got it from kegel exercises gone wrong. since this phenomenon is going on, and there’s not really any science or literature prompting people how to do properly without injury… you are taking a risk by doing it. like i said, it MAY help people if you do it right or know what you are doing or don’t over do it… but you’re taking a risk none the less since this stuff isn’t researched and not really well known. please don’t promote stuff on here that may bring devastating side effects to someone else. for people that are in bad shape, and then if they overdo these kegel exercises desperate to get better, they may do more good than bad.

I’m not talking about hardcore penis exercises. I’m talking about kegel exercises. There are a lot of studies that shows how effective (and safe) kegel exercises are, both natural and with the help of electric equipment. Those studies are done on both men and women, and solves problems with incontinence, ED and pleasure during sex. Women who have given birth, and men who have gone through prostate treatment or surgery should do them regularly. Kegel exercises are some specific exercises that were developed by a doctor - and they’re recommended by everyone else, so I suggest that you do some more research.

This is something to help you get started

Pelvic floor exercises for erectile dysfunction.
Dorey G, Speakman MJ, Feneley RC, Swinkels A, Dunn CD.
Source

The Somerset Nuffield Hospital, Taunton, UK. grace.dorey@virgin.net
Abstract
OBJECTIVE:

To examine the role of pelvic floor exercises as a way of restoring erectile function in men with erectile dysfunction.
PATIENTS AND METHODS:

In all, 55 men aged > 20 years who had experienced erectile dysfunction for > or = 6 months were recruited for a randomized controlled study with a cross-over arm. The men were treated with either pelvic floor muscle exercises (taught by a physiotherapist) with biofeedback and lifestyle changes (intervention group) or they were advised on lifestyle changes only (control group). Control patients who did not respond after 3 months were treated with the intervention. All men were given home exercises for a further 3 months. Outcomes were measured using the International Index of Erectile Function (IIEF), anal pressure measurements and independent (blinded) assessments.
RESULTS:

After 3 months, the erectile function of men in the intervention group was significantly better than in the control group (P < 0.001). Control patients who were given the intervention also significantly improved 3 months later (P < 0.001). After 6 months, blind assessment showed that 40% of men had regained normal erectile function, 35.5% improved but 24.5% failed to improve.
CONCLUSION:

This study suggests that pelvic floor exercises should be considered as a first-line approach for men seeking long-term resolution of their erectile dysfunction.

Pelvic floor exercises for erectile dysfunction.