Accutane user just beginning to put the pieces tgether

Member Stories
, ,
#21

Hi everyone,

I just wanted to post something fascinating that I’ve been coming across as I try to make sense of the connections between my symptoms. The first article is research conducted on mice in which Accutane was intentionally used to cause an increase in Mast cells for the purpose of wound healing. Mast cell activation is the cause of MCAS/MCAS. The second study articulates that the reason photosensitivity is a side-effect of Accutane is related to “degranulation” of Mast cells, which is basically a way in which they become destablized/activated.

Please let me know if you are female and are "double jointed’, prone to (joint dislocation), have pelvic, sacral or urinary pain, and/or believe you developed “allergies” or food sensitivities after using Accutane. It would be my honor to help you get diagnosed with MCAS and/or EDS sooner than the 14 years it took me.

STUDIES


https://onlinelibrary.wiley.com/doi/abs/10.1111/j.1468-3083.1993.tb00006.x

#22

Are you experiencing increased wound healing now?

#23

Hi Calcified,

I don’t have any special powers with wound-healing, if that’s what you’re asking lol

The idea of the study is that any trauma to the body triggers the release of certain cells to repair and protect the body. The researchers discovered that giving the rats Accutane made their wounds heal faster by activating a type of response cell called a Mast cell. The problem is, if you have the genetic propensity for conditions like MCAS or Mastocytocis, you’re going to have a really big problem taking any medications that “degranulate” or activate Mast cells intentionally, because you either have two many Mast cells or you have unstable Mast cells.

The reason I am interested in this study is because I have recently been diagnosed with MCAS, and I am very very clear that I never had “allergies” or inflammation prior to Accutane. I am beginning to understand that my Accutane treatment may have been my first MCAS “flare up”.

#24

Only asked as people have complained of slow wound healing now.

#25

Oh interesting. Did not know that!

#26

I too believe I have MCAS and POTS and even EDS. This all started after coming off SSRI and taking Sam-e. The Sam-e is what really did it but I believe the SSRI laid the groundwork. I notice improvement when on antihistamine and mast cell stabilizers. Licorice Root really helps my sexual issues and I just learned that its a mast cell stabilizer and helps nerve function. Going to start working with a MCAS specialist soon and will report anything useful back. But this explains my symptoms really well.

#27

Oh man.
I have always been living with cats until one day i developed allergy to them.
I have never consider accutane to be the cause, because i got PFS from finasteride many years after that. But, i just realize that i got cat allegy more or less when i was on accutane or after cessation. Very interesting.