Abstracts of Articles to Be Presented at Conference in Italy

Science PFS Research
#61

The people involved with the foundation have full time demanding day jobs. Just filing for non-profit/tax exempt status is a long drawn out project. The only thing I do really know about medical research is that it takes alot of organizational work, fund raising, etc. There are only a few individuals involved that are qualified to get this type of work done. Hopefully they will get the credit they deserve for doing this some day. Not to sound harsh but it just isn’t their function to respond to our every question nor do I think we should expect them to considering what they have on their hands now. Just look at the foundation’s current research projects page to get a sense of it. Again, there have been updates on the foundation’s website fairly regularly when you consider research takes months, years. I’m sure there will be more updates as things move forward.

ps- I don’t think it’s common practice for most not for profits to post a running tally of what they’ve raised. People can give what and if they can. I don’t understand what it matters in terms of what you donate. They have multiple projects in the works which is really the important thing at the end of the day. They do have to publicly report what they raise when they file their tax returns away.

#62

Is it really? Many of the people here have normal DHT.

#63

Yes serum DHT. 3 Adiol G is a much better marker for 5 AR activity than serum DHT.

Androstanediol is a breakdown product of dihydrotestosterone and its glucuronide. Androstanediol Glucuronide has been used as a marker of target tissue cellular action. There is excellent correlation between the serum levels of Androstanediol Glucuronide and the clinical manifestations of androgens. Specifically, 3 alpha-Androstanediol Glucuronide correlates with the level of 5 alpha reductase activity (testosterone and Androstanediol to dihydrotestosterone) in the skin. Androstanediol is not solely a measure of cutaneous androgen metabolism but also reflects specific types of liver function and the impact of major precursors which derive from the adrenal gland. Hirsutism is a condition of abnormal body hair, occurring especially as an adult male pattern of hair distribution in women. The Androstanediol Glucuronide Test is a test used to aid in the diagnosis of this condition and the presence of androgen activity (male hormone) in the skin. Hirsutism (Hypertrichosis) is not a disorder of hair, but reflects increased 5 alpha reductase (an enzyme found in the male prostate) which produces more DHT (dihydrotestosterone, a highly active form of testosterone), leading to the stimulation of hair growth in areas that are not usually hairy.

Interesting that it denotes specific types of liver function as well… wish they would elaborate on that.

#64

BP the only issue I see with that is a good number of guys have had normal to even high 3a diol g levels come back. How can we explain that if 5ar is the big issue?

#65

I don’t think its the only issue at play. Afaik I only saw one or two people with good 3 adiol g levels… and a couple guys increased it on trt.

The point was that it is clear that the vast majority of us have screwed up 5 AR… not that this is the only or even the root problem that we have.

#66

That metabolite is measured so rarely that I wouldn’t take the reference values very seriously either. And when you look at the thread, many of the sufferers have it normal. We can’t talk about supressed 5ar2: we would be keeping our hair otherwise. I think it’s enough to read the tens of studies that describe the DHT levels return to believe it. Every now and then in this forum someone has tried to question it and has been proven wrong.
Of course, it seems everybody here has their own favorite theory, so it’s cool for you to pick one too.

#67

Then why read this thread since in the articles presented the researchers found low 5 ar metabites in csf… if you in fact do not believe this is the case? Which theory do you support if any?

#68

Apparently there was an almost complete absence of allopregnanolone and isoallopregnenolone in the CSF of those studied. There was also low DHT, and in one case abnormally low level of pregnenolone. Whilst neurosteroids where also low in plasma.

#69

Where do you get this info? I so want to read the full text already.

#70

Wow, that’s been my assumption for a while. At some point finasteride completely abolishes the protective affects of neurosteroids! This would certainly explain the guy who takes one damn pill of this. I’m telling you guys, in my opinion we fix this, we fix PFS. Completely diminished levels of Allopregenalone is mind boggling.

#71

Hej Finatruth

Could my problem be completely abolishes the protective effects of neurosteroids and diminished levels of Allopregenalone.

I have now for a year felt a pressure or tightness in my forhead.
A kind of pain or headache sometimes with nausea.

It is always worse when I try to sleep, like a switch being turned off in my brain, prevent me from falling asleep and I wake up with an tremor in forhead and higher pulse, it happen a lot of times during the night.

#72

Care to share where you read/heard that there was almost a complete absence?

Last I read, you were arguing that Finasteride does not inhibit nuerosteroids…
viewtopic.php?f=1&t=5960

#73

Has anyone tried supplementing with pregnenolone cream? If so what happens?

#74

Yes, not much of anything happens for me. If I can tell my cortisol is low, sometimes applying perg cream helps slightly with low cortisol symptoms, but its much easier and faster to just take isocort.

#75

Has there been any update about what was talked about at the conference? I was expecting we would hear about what was discussed at the conference but instead we haven’t heard anything? This is really strange.

#76

I wouldn’t be too discouraged or read too much into that. I’m sure AWOR will update when he has the chance. The abstracts are available to look through to draw your own conclusions and it was posted before AWOR was pleased overall with how things went.

#77

yeah I agree something should surface soon. The only think that bothers me is that this site is the mecca for PFS sufferers. Can’t really find any other websites. This is also the site where Dr. Jacobs and other PFS docs get probably all there business. I understand the foundation is busy, but if they were just once to reach out to this site of followers (organization) I am sure the credibility factor as well as donations woud soar. Unfortunately we are the target group of sufferers as highlighted on FOX news, NBC, and ABC networks.

#78

It doesnt. A crucially overlooked point.

#79

What? Are you still trying to say fin doesn’t inhibit production of allopregnanolone :smiley:?

#80

Just a reminder…

bio.net/bionet/mm/neur-sci/2 … 58929.html