they are fine. thanks for the concern.
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Thanks for posting. It’s good to hear that you are able to live a good life. I’ve had some benefit taking Ciallis etc, but haven’t really thought about the 5mg a day option. I think that’s it’s best to try and find what helps in the meantime until we know more from research and new treatments. I understand what you mean about the psychological impact of pfs, which is very difficult to deal with and makes the symptoms worse.
Genetic conditions aren’t always noticeable, they may appear later in life.
I just think it’s irresponsible to have kids after having PFS. Whether you knew it or not you gambled with your life and now you’re gambling with the lives of others.
There’s no evidence of that either scientifically or anecdotally at this point, so I don’t think it’s considerate to be alarmist or chastising regarding his children. He’s reporting a very mild case in just having treatable ED, and seeing as several quite severe cases have had kids who have been OK, I don’t think it’s a good idea to worry someone with no basis. It could be upsetting.
Finasteride is not mutagenic and what is being indicated by the scientific direction of PFS (changes to gene expression) could very likely be removed by the egg in the zygote stage if it got that far, as methylation is (largely) stripped at this point to put the epigenome in a ‘reset’ totipotent situation.
Ppcia, glad to hear you’re able to live a full life and you seem to be able to manage your condition with Cialis.
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I think it’s a good idea to be worried. The ED isn’t the issues here, the stuff makes your sperm watery which isn’t normal, the safe bet is to just not have children. It’s actually inconsiderate to just ignore the problem and have kids anyway.
I am not worried. I have a very solid understanding of the biology here. And you can’t live your life in worry.
OP congratulations on feeling better and becoming functional once again.
There’s nothing proven on passing down PFS to your kids, or genetic diseases derived from pfs. No need to be worried about this, especially if the kid is already born.
In fact others had kids before , some should be now going through puberty or pre puberty. No cases reported about pfs passing down to the next generation, no reports of unhealthy kids either.
I see there’s quite a few non responders to pde5 inhibitors among pfs population. Statins come with their risks too, and they may even lower testosterone, but seems like there’s some evidence for its use in pde5 non responders, if you ever happen to become one. This is from a review of 2017.
Good luck
Theoretically, statins seem to be a double-edged therapy for patients with ED. Although our study revealed positive consequences of these lipid-lowering drugs on erectile function, especially for patients with no response to PDE5Is, the study was limited in the number of RCTs included and high heterogeneity existed in the meta-analysis. Hence, additional large, well-designed RCTs with high-quality are needed to explore the general effects of statins for the treatment of ED…
All these “there’s nothing proven statements” sound exactly like the pro-fin people/companies saying PFS isn’t proven yet. This is a legitimate concern and you guys are just brushing it off completely, that’s worrying. This topic is barely discussed and this is the only drug that directly affects the prostate, it’s foolish to dismiss it. Even if a study says it doesn’t I’d be willing to bet it’s wrong.
This drug has only been out for less than 30 years so far. I repeat genetic problems aren’t always noticeable. So the oldest offspring would have to be around that age of 30 and I bet if they’re just getting problems they’re not gonna attribute it their dad taking finasteride decades ago.
Trump’s on finasteride and his kid has autism. Old age already increases the possibility of genetic problems, you mix in finasteride use and I bet the possibility increases even futher. That kid barely had a chance probably.
@lbv we arent brushing it off, its just that there is no need to be alarming OP on this because there is no evidence of this being a problem (not even anecdotes, much unlike PFS) for the time being and he already had the kid anyway which defeats the purpose of your advice.
He came here to cheerfully say his life is going on. People who can, move on with their lives as they normally would. Theres been lots of PFS patient´s born kids.
if you are concerned about discussing or bringing this to attention, the best you can do is to open a thread about it. FYI this concern has been brought up many times in the past.
Dont think theres been any study about finasteride and autism in offsprings, but finasterides teratogenic effects are well documented. People shouldnt conceive on Finasteride and i must add, PFS is different from being on Finasteride.
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just to add one or two things to my story:
- initially I was not responsive to the pde inhibitors, not 5mg and not 25mg of cialis. it was only after months of daily use.
- in the first year of using propecia I did have some other issues, like an episode of depression (never before having had this) and also a personality change which I recognize only in retrospect. but yes most symptoms were ED.
thanks for this input.
indeed i have seen a lot of PDE5i unresponsive people. Some initially and some just developed it after continuous use. But it seems like this is not PFS specific, other people report being unresponsive to PDE5 inhibitors. I found this review yesterday and it caught my attention. they get into the possible mechanisms too.
What sort of personality change did you get, if its possible to describe it?
Initially all I said was don’t be surprised if genetic conditions arise. And he denied it was a possibility so I was educating him and any potential lurkers. Also I wanted to get onto him for not even thinking about it before deciding to have kids. You can’t let that slide. Plus If I was his kid, I would want an explanation if anything did occur. Now if it does he can tell his kid what’s up.
It doesn’t sound anything like that… PFS has many thousands of anecdotal reports and a growing body of scientific evidence. There’s neither for that claim, nor a sound theoretical basis in reproductive biology, which is what I pointed out. I get it’s a gut feeling you personally have and that’s fine, but it seemed like a moral judgement on irresponsible behaviour which is not really credible or fair.
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@lbv
Any men who took fin are lucky to escape with their lives but any who let their perfectionism about the things fin changed turn into an evolutionary dead-end are fools. There’s a bigger world out there, take a look at the average person these days. The men on this forum are of above average intelligence so even if one or more of their children are born with problems they will still be a better contribution to the world even if they only have 20 or 30 years to work with than the millions and billions of morons walking amongst us.
lol ppl here are above average? I think we’re all idiots, drugs have been around forever, you can’t take a new drug that’s only been around a few decades, it’s not long enough to judge the safety profile, so I think the excuse “I didn’t know” is pretty weak for most of us.
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very hard to describe. it was subtle but I think perhaps an emotional blunting and decreased sociability. loss of sexual interest.
Hind-sight is 20/20, I didn’t say the men here were smart, I only said they are of above-average intelligence if you step out of your bubble. You being considerate to your unborn children won’t prevent millions of turds from having their litter.
I’m in a related situation… I used Procar last year for two months at the age of 55. I now have no function unless I use Cialis, etc… and I still have issues around lack of dopamine …not as much enjoyment for it
Hello this cialis regimen also worked on me but main thing we have to live rest of our lives by taking cialis… i want to be normal again…
Some people said that it is dangerous for eyes it is not true tadadafils action is not on eye, other pde5 inhibitors affects cellular actions of retina cells, not tatadafil though it dilates prostat glands blood vessels.
I understand your feeling. I dont believe anybody who had this bad luck will return to their previous level of function. I consider myself lucky now to find a way to at least have a tool to manage this. for me I’ve been living a “normal” life again for the last 8 years or so. I’m already into the second half of my life. I cant get back what I lost, but I’m going to make the best of my future.
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