To Mohi Khera, Baylor University
Hello Dr, Thank you for your response
I just want to pass you an information that could also help you out to find answers and even a possible treatment
The following study and research indicated that SRD5A2 is silenced in prostate tissue.
Variable expression of 5-alpha reductase 2 in the aging adult prostate is regulated by DNA methylation
5-alpha reductase type 2 (SRD5A2), an enzyme that is critical for prostatic development and growth, is utilized as an inhibitory target by finasteride for patients with bladder outlet obstrution secondary to BPH. However, we have found that many aging benign prostate tissues do not express the enzyme. Since the SRD5A2 promoter contains a CpG island, we hypothesized that somatic methylation of the promoter would be regulated by DNA methyltransferases leading to suppression of SRD5A2.
We found that methylation of SRD5A2 was regulated by DNA methytransferase 1 (DNMT1) and the cytokines, TNF-alpha, NF-κB and IL-6, regulated DNMT1protein expression and thereby indirectly affected SRD5A2 promoter methylation and gene expression.
Induction of inflammation with lipopolysaccharide (LPS) stimulated the TNFR1/NF-κB/IL-6/DNMT1 pathway, leading to hypermethylation of the SRD5A2 promoter and silencing of SRD5A2, while treatment with both LPS and TNF-alpha inhibitor reversed this pathway and reactivated SRD5A2.
From Propecia Help Forum
I found a guy that his symptoms were reversed, by accident when his doctor administered intravenous 1000 mg of methylprednisolone for 5 days, 5 months later his sexual functions including libido was 100% restored and all the others symptoms disappear.
only his sleep remain dysfunctional.
For those who doesn’t know methylprednisolone is a LPS and TNF-alpha inhibitor, is an immune suppressant.
I hope that every one got the idea.
Gentlemen believe or not, we are in from of a possible miracle cure if methylprednisolone is used within the proper protocol and the right dosage.