I stumbled upon this excerpt on NCBI:
" Additionally, lower levels of IL-6 were associated with age-related increase of ED, which further confirms the hypothesis of an association between inflammation and ED. The levels of several proinflammatory cytokines are also elevated in cardiac dysfunction, and the administration of phosphodiesterase type 5 inhibitor such as sildenafil was reported to cause a sustained reduction of proinflammatory cytokines, linking the influence of proinflammatory cytokines on vasculogenic function and ED ."
Again, this goes to show that inflammation may be a major player in erectile dysfunction problem. I previously posted about my personal experience with certain Probiotics triggering high histamine release and resulting in increased inflammatory response (immune response) that led to absent morning erections. I’ve a strong feeling we should diagnose and treat any inflammation mainly in the gut. Gut inflammation usually represents itself as IBS.